Gastrointestinal stromal tumours (GIST) are rare mesenchymal neoplasms that can develop in the entire length of the gastrointestinal tract or sometimes from the omentum and mesentery. In most cases, they arise from the stomach, less often the jejunum or ileum. We report the case of a 53-year-old-female patient, without significant medical history, consulting for chronic epigastric pain, with no other associated signs. She had underwent an abdominal ultrasound completed with a Contrast-enhanced computed tomography (CT) of the abdomen showing a large tissular mass developed at the expense of the cephalic portion of the pancreas, with central calcifications and heterogeneous enhancement after contrast injection. Pancreaticoduodenectomy, partial colectomy and antrectomy has been performed and histological examination with immunohistochemical study had concluded the diagnosis of pancreatic primary GIST.
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