Pancreatic Gastrointestinal Stromal Tumour: A Case Report and Review of the Literature

Daadoucha, A.; Waad, Farhat; Mabrouk, Mohamed Ben; Harrabi, Fathia; Mohamed, Abdelrahman; Ali, Ben Ali

doi:10.4236/jct.2017.811085

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…In such cases, the identifcation of an asymptomatic, singular, and large mass exhibiting distinct radiological features becomes pivotal. Such features may include a well-circumscribed lesion displaying central necrosis and calcifcation, as discerned through an abdominal CT scan [3,[7][8][9]. Tese radiographic fndings may raise suspicion of either pancreatic metastasis or pancreatic GIST.…”

Section: Clinical Discussionmentioning

confidence: 99%

Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland

Marbun,

Jamtani,

Krisnuhoni

et al. 2023

Case Reports in Medicine

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Pancreatic gastrointestinal stromal tumors (PGISTs) are exceptionally rare, accounting for <5% of extra-gastrointestinal stromal tumors (EGISTs) and <1% of malignant pancreatic neoplasms. We present a unique case of concurrent double primary malignancies in a 46-year-old female with a history of recurrent myoepithelial carcinoma of the parotid gland, managed through surgical resection and adjuvant therapy. She presented with an enlarging abdominal mass, initially suggestive of pancreatic metastasis. Immunohistochemical analysis revealed positive staining for smooth-muscle actin (SMA) and CD34 in both parotid and pancreatic tissues. Importantly, CD117 expression was confined to the pancreatic tissue, confirming the diagnosis of PGIST rather than metastasis. Subsequently, a splenic-sparing distal pancreatectomy was performed, followed by immediate imatinib therapy. This case underscores the potential for the coexistence of rare primary malignancies with unique histopathological characteristics and organ involvement. When encountering a newly developed lesion in a distant organ, surgeons must consider the possibility of metastasis to guide therapeutic decision-making. Early diagnosis and appropriate intervention are paramount, particularly in the case of PGIST, given its infrequent presentation and clinical complexities.

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Section: Clinical Discussionmentioning

confidence: 99%

Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland

Marbun,

Jamtani,

Krisnuhoni

et al. 2023

Case Reports in Medicine

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Primary Pancreatic GIST — A-Single Centre Case Series and Systematic Review of Literature

Gupta,

Chopde,

Chaudhari

et al. 2024

J Gastrointest Canc

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There is evolving literature on similarities and differences between GIST and EGIST. Despite their behavioural similarities, results cannot be generalised to larger population due to lack of evidence. Pancreatic GIST is a rare entity. There are many documented case reports, however long term data is unavailable. Our case series is by far the largest single centre series with long follow up data but with limited number of cases. Survival values cannot be generalised due to limited data. Large case series are required to further understand the disease biology and long term outcomes of pancreatic GIST.The median tumor size was 6 cm (2-18 cm). Mitotic index of 5 patients were < 5/50 hpf (high power eld) whereas data was not available for 4 patients and 4/8 patients were categorised as high risk as per NIH (National institute of health) risk category. Six patients displayed solid mass on cross-sectional imaging.All patients had spindle morphology on histopathology. Three patients had exon 11 kit mutation on further analysis. Two patients had recurrence with site being liver in both of them. Review of literatureA total of 57 patients were identi ed from 51 published articles. Clinicopathological characteristics of all patients have been summarised in table 1b. All patients belonged to a median age group of 55 years (30-84 years). There were 47% females (n=27) and 45% males (n=26). The most common location was pancreatic head/uncinated process (n=35) followed by body/tail (n=18) with one patient having involvement of entire pancreatic tissue. The majority of patients underwent Whipple procedure or distal pancreaticosplenectomy (DPS) as per tumor location. The median tumor size was 7 cm (0.8 to 35 cm). 18 patients had mitotic count >5/50 hpf and 23 patients

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Primary Pancreatic GIST- A single centre case series and systematic review of literature

Gupta,

Chopde,

Chaudhari

et al. 2023

Preprint

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Pancreatic Gastrointestinal Stromal Tumour: A Case Report and Review of the Literature

Cited by 3 publications

References 15 publications

Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland

Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland

Primary Pancreatic GIST — A-Single Centre Case Series and Systematic Review of Literature

Primary Pancreatic GIST- A single centre case series and systematic review of literature

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