Abstract:We propose ultra-high resolution optical coherence tomography to study the morphological development of internal organs in medaka fish in the post-embryonic stages at micrometer resolution. Different stages of Japanese medaka were imaged after hatching in vivo with an axial resolution of 2.8 µm in tissue. Various morphological structures and organs identified in the OCT images were then compared with the histology. Due to the medaka's close resemblance to vertebrates, including humans, these morphological features play an important role in morphogenesis and can be used to study diseases that also occur in humans. References and links1. J. Wittbrodt, A. Shima, and M. Schartl, "Medaka--a model organism from the far East," Nat. Rev. Genet. 3(1), 53-64 (2002). 2. T. Iwamatsu, "Stages of normal development in the medaka Oryzias latipes," Mech. Dev. 121(7-8), 605-618 (2004). 3. T. Iwamatsu, "Growth of the Medaka (I)-Formation of Vertebrae, Changes in Blood Circulation, and Changes in Digestive Organs," Bull. Aichi Univ. Educ. 61, 55-63 (2012). 4. J. Finn, M. Hui, V. Li, V. Lorenzi, N. de la Paz, S. H. Cheng, L. Lai-Chan, and D. Schlenk, "Effects of propranolol on heart rate and development in Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio)," Aquat. Toxicol. 122-123, 214-221 (2012). 5. M. Islinger, D. Willimski, A. Völkl, and T. Braunbeck, "Effects of 17a-ethinylestradiol on the expression of three estrogen-responsive genes and cellular ultrastructure of liver and testes in male zebrafish," Aquat. Toxicol. 62(2), 85-103 (2003). 6. J. Zha and Z. Wang, "Assessing technological feasibility for wastewater reclamation based on early life stage toxicity of Japanese medaka (Oryzias latipes)," Agric. Ecosyst. Environ. 107(2-3), 187-198 (2005). 7. C. Cubbage and P. Mabee, "Development of the cranium and paired fins in the zebrafish Danio rerio (Ostariophysi, Cyprinidae)," J. Morphol. 229(2), 121-160 (1996). and their relation to neuromeres and migration (secondary matrix) zones,"
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