• This is the first trial to explore the neoadjuvant therapy of pyrotinib in HER2-positive operable and locally advanced breast cancer, in combination with epirubicin plus cyclophosphamide followed by docetaxel plus trastuzumab. • Results primarily showed that pyrotinib in combination with epirubicin plus cyclophosphamide followed by docetaxel plus trastuzumab was effective and safe in HER2-positive operable and locally advanced breast cancer. • A subsequent randomized controlled trial is still warranted to confirm these results.
Peripheral
nerve injuries represent a great challenge for surgeons.
The conductive neural scaffold has experienced increasing interest
because of its good biocompatibility and similar electrical properties
as compared to those of a normal nerve. Herein, nerve conduits made
from poly(d,l-lactide)-co-poly(ethylene
glycol) and polypyrrole (20%, 30%, and 50%) (PELA–PPY) were
prepared by electrospinning, and used in regeneration of peripheral
nerve defects. The results of an in vitro experiment
indicated a high biocompatibility for the as-prepared materials, supporting
the attachment and proliferation of a rat pheochromocytoma PC-12 cell.
Furthermore, the PELA–PPY nerve conduit implanted in the sciatic
nerve defects (10 mm) of the Spraguee–Dawley rats for 12 weeks
showed similar results with the autograft, while it demonstrated a
better outcome than the PELA nerve conduit in electrophysiological
examination, sciatic function index, total amount of regenerated myelinated
nerve fibers, axon diameter, myelin thickness, and several immunohistochemistry
indices (S-100, laminin, neurofilament, bromodeoxyuridine, and glial
fibrillary acidic portein). We supposed that the bioactivity is mainly
generated by the PPY in composite nanofibers which could transmit
self-originated electrical stimulation between cells. Due to the facile
preparation and excellent in vivo performance, the
PPY–PELA nerve conduit is promising for use as a bioengineered
biomaterial for peripheral nerve regeneration.
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