Despite concerted efforts to eradicate malaria, it is still one of the most devastating infectious diseases in the tropics due largely to emergence and widespread P. falciparum drug resistance. This research investigated the in vitro antimalarial susceptibility of Plasmodium falciparum isolates from patients attending Plateau State Specialist Hospital, Jos, Plateau State, Nigeria, using the World Health Organization (WHO) standardized in vitro micro-test system. Foremost, the records of reported malaria cases in the hospital were collated for the prevalence of malaria and the frequency of commonly prescribed antimalarial drugs were ascertained. A total of 7936 persons comprising of 3659 males (46.11%) and 4277 females (53.89%), were reportedly infected with malaria parasite from January 2013 to December 2014 in the hospital studied. Blood samples were collected from 131 volunteered patients. Of these samples, 114 (87.02%) had malaria parasites, with 108 (94.74%) samples positive for P. falciparum. Of 88 P. falciparum isolates used for in vitro antimalarial susceptibility test, 33 (37.50%), 27 (30.68%), 22 (25.00%), 22 (25.00%), and 22 (25.00%) were resistant to chloroquine, artemether, amodiaquine, artesunate, and lumefantrine respectively. This study showed the presence of resistant P. falciparum in the study area. Adoption of efficient intervention strategies is warranted in order to curb increase in antimalarial drug resistance.Keywords: Samples, parasite, resistance, study, positive, prescribed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.