Background: To study the role of single nucleotide variants (SNVs) of genes related to preeclampsia in Pakistani pregnant women. Methods: After ethical approval and getting informed consent; 250 pregnant women were enrolled and equally divided into two groups (125 preeclamptic cases and 125 normotensive pregnant women). Demographic details and medical history were recorded, and 10 ml blood sample was obtained for DNA extraction. The tetra-primer amplification refractory mutation system (ARMS) assays were developed for assessing the variants of three preeclampsia related genes; F5, MTHFR and VEGFA. An association of six SNVs; F5:c.1601G > A (rs6025), F5:c.6665A > G (rs6027), MTHFR: c.665C > T (rs1801133), MTHFR: c.1286A > C (rs1801131), VEGFA: c.-2055A > C (rs699947) and VEGFA: c.*237C > T (rs3025039) with preeclampsia was determined by using different genetic models. Results: Genotyping of the SNVs revealed that patients with MTHFR:c.665C > T, have increased susceptibility to preeclampsia
Preeclampsia is the complex disorder characterized by hypertension and proteinuria. Preeclampsia if complicated can progress to eclampsia, endangering life of both mother and fetus. Eclampsia occurring during delivery is referred as intrapartum eclampsia. Few studies have been conducted on intrapartum eclampsia, as it is less frequent in developed countries due to the availability of better health care facilities and awareness. Here we report a case series of patients presented with intrapartum eclampsia presented at a tertiary care hospital.
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