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The present study was undertaken to evaluate the peroxidative damage and hypercholesterolemia induced in male Wistar albino rats by diets enriched either with 1% oxidized cholesterol (OC) (containing 49.8% of cholesterol oxidation products) or pure cholesterol (PC). The damage caused by the OC diet was revealed by a significant rise in red blood cell hemolysis, increased tissue lipid peroxidation and elevated aspartate amino transferase activity as compared with control and PC diets. Liver glutathione-S-transferase activity was decreased by both OC (P < 0.01) and PC (P < 0.05) diets, but glutathione was observed to be decreased only by the OC diet. Plasma triacylglycerol and cholesterol were increased significantly with both the OC and PC diets. Liver cholesterol and triacylglycerol were increased significantly with the OC diet only. These results indicate that the oxidative damage caused by the OC diet is much more pronounced than that caused by the PC diet.

Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease caused by lymph dwelling filarial parasite of human viz., Wuchereria bancrofti, Brugia malayi, Brugia timori, Caenorabditis elegans. Worldwide more than 880 million people in 51 countries remain at risk of infection. 1 The mass drug administration (MDA) programme of WHO recommended albendazole (ALB) diethylcarbamazine (DEC) and ivermectin (IVM) drugs in combination once in a year for the control of LF. 2 The available antifilarial drugs only kill microfilariae without affecting the adult parasite 3 thus effective chemotherapy for lymphatic filariasis is still lacking. This problem makes it essential to look for specific vaccine or diagnostic marker to control the disease. The classical methods for diagnosis are detection of microfilariae in human blood sample is time dependent thus making the diagnosis difficult. The filariasis test strip (FTS) is commercially available diagnostic kits for LF. This is a very good marker for LF and easy to use but it is very costly to monitor global elimination programme in endemic countries having huge economic burden. An ideal diagnostic marker for LF should have

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