Both occult and non-occult forms of HCV infection are more prevalent than HBV infection in hemodialysis patients. Especially the patients with isolated anti-HBc positivity should be tested for probable occult hepatitis B infection.

Vitamin E treatment, in addition to its previously shown beneficial effect by suppressing oxidative stress, may also achieve improvement by reducing IR and PPAR-alpha expression in NASH.

(1 g/day, orally) for a median duration of 7 months (range, 6-11 months) initially, whereas the remaining patients (9 Stage B patients and 7 Stage C patients) received 1 Department of Medical Oncology, Ibn-i Sina combination chemotherapy (cyclophosphamide, vincristine, procarbazine, and Hospital, Ankara University School of Medicine, prednisolone [COPP regimen]) followed by tetracycline at a dose of 1 g/day for 6 Sihhiye-Ankara, Turkey.more months in patients with complete response (CR) after the COPP regimen. 2 Department of Gastroenterology, Ibn-i Sina RESULTS. The median follow-up was 68 months (range, 38-89 months). As first-Hospital, Ankara University School of Medicine, line therapy in Stage A patients, tetracycline yielded a 71% CR and 43% disease Sihhiye-Ankara, Turkey.free survival (DFS) rate. Eleven of 16 patients (69%) with Stage B or C disease who 3 Department of Third Internal Medicine, SSK received the COPP regimen achieved CR and only 2 patients had a recurrence Hospital, Diskapi-Ankara, Turkey.(DFS rate of 56%). The 5-year overall survival (OAS) rate for the entire group was 70%, and the 5-year DFS rate for patients with CR was 75%. However, the median

In this sample group from a developing country H. pylori infection was not shown to be associated with atopic diseases. Therefore, the eradication of H. pylori may not be assumed to have an effect on allergic inflammation.

No abstract

Familial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder characterised by recurrent and self-limited abdominal pain, synovitis and pleuritis. MEFV gene mutations are responsible from the disease and its protein product, pyrin or marenostrin, plays an essential role in the regulation of the inflammatory reactions. MEFV gene contains 10 exons and most of the mutations have been found on the last exon. Up to date, 152 mutations and polymorpisms have been reported inwhere V726A, M694V, M694I, M680I and E148Q are the most common mutations. In this study, MEFV allele frequencies of 136 individuals (60 from Pediatry, 76 from Internal Medicine) have been evaluated, and compared with each other. Asymptomatic individuals with FMF family history (4 from Pediatry, 6 from Internal Medicine) were excluded from the analysis. The prominent mutations indicated in the Pediatry group are V726A, M694V and M680I (G/C) and with the allele frequency of 0.06, 0.05 and 0.04 respectively while they were E148Q, M694V, M680I (G/C) in the Internal Medicine group with the allele frequency of 0.12, 0.08 and 0.04. The E148Q mutation is significantly overrepresented in the adult referrals (P = 0.02). Mutation on both alleles was observed in only 12% of cases. Overall mutation frequency was low, seen in 26.2% (66/252). However, when only diagnosed patients were analyzed it is 72.7% (16/22). It is also interesting that 63% of individuals are female that there may be sex influence on FMF phenotype.

AIM:To investigate the prevalence of coeliac disease in a series of Turkish patients with autoimmune thyroiditis.

Background:Free radicals have a pivotal role in the pathogenesis of non-