This article summarizes the major categories of ethical violations encountered during submission, review, and publication of scientific articles. We discuss data fabrication and falsification, plagiarism, redundant and duplicate publication, conflict of interest, authorship, animal and human welfare, and reviewer responsibility. In each section, pertinent historical background and citation of relevant regulations and statutes are provided. Furthermore, a specific case(s) derived from actual situations is(are) presented. These cases were chosen to highlight the complexities that investigators and journals must face when dealing with ethical issues. A series of discussion questions follow each case. It is our hope that by increasing education and awareness of ethical matters relevant to scientific investigation and publication, deviations from appropriate conduct will be reduced.
In this work, a novel compact and accurate glucose concentration measurement system is developed using the well-established photoacoustic Near Infra-Red spectroscopy. The proposed invitro instrumentation methods are in a small form factor, making it a viable candidate and precursor for an in-vivo non-invasive wearable blood glucose monitoring in the near future. The accuracy comes from the phase sensitive detection of the electrical signal. This detection technique uses an off-the shelf modulator/demodulator integrated circuit configured as a lock-in amplifier to increase the signal to noise ratio multifold. No prior work on photoacoustic spectroscopy, has taken advantage of this detection methodology in such a small form factor. The dimension of the lock-in-amplifier is 13mm x 10.65mm x 2.65mm. The maximum linear dimension of the exciting laser is 5.6 mm. The acoustic sensor (transducer) has a dimension of 42mm x 12mm. Furthermore, the measurement and analyses of the observed data uses multiple stochastic and machine learning techniques to bring out the best correlation fit between the glucose concentration and a specific feature of the electrical signal. With these methods and techniques, a strong correlation was confirmed between the glucose concentration and the amplitude of the electrical signal. The computed correlation coefficient between the signal amplitude and glucose concentration is 97% while the p-value is 5.6E-6. To the best of our knowledge, this is the first work to report photoacoustic spectroscopy for glucose concentration measurement in a compact form, with lock-in amplifier and aided with machine learning algorithms for future application as a wearable device.INDEX TERMS photoacoustic NIR spectroscopy, non-invasive glucose monitoring, lock-in-amplifier, machine learning
Background The aim of this study was to determine the frequency of hypoalbuminemia and in-hospital mortality in acute ischemic stroke patients at a tertiary care hospital in Hyderabad. Methodology This was a prospective observational study conducted at the Department of Medicine, Isra University Hospital, Hyderabad, from February 17, 2017 to August 18, 2017. A total of 196 consecutive cases of acute ischemic stroke were included. Hypoalbuminemia was defined as serum albumin of <3.5 mg/dL. In-hospital outcome in terms of survival or death within seven days of admission was assessed and recorded. Data were analyzed using SPSS, version 20.0. (IBM Corp., Armonk, NY, US). Chi-square test was applied, and p-value of ≤0.05 was considered significant. Results Out of the 196 acute ischemic stroke cases, 146 (74.5%) were males and 50 (25.5%) were females. The mean age was 49.31 ± 10.46 years. A total of 90 (45.9%) cases had hypoalbuminemia. Out of these 196 cases, 22 (11.2%) expired within seven days of presentation of acute ischemic stroke, and out of these 22 expired cases, 18 (81.8%) had hypoalbuminemia. In-hospital mortality was found to be strongly associated with hypoalbuminemia (p < 0.001). Conclusions Frequency of hypoalbuminemia was significantly higher in ischemic stroke patients and was found to be associated with in-hospital mortality, warranting monitoring at regular intervals, as well as recognizing and treating it early for risk stratification.
Objectives: To evaluate the individuality of palatal rugae patten and correlate them in males and females in different age groups by using Trobo’s classification. Study Design: Cross Sectional. Setting: Department of Prosthodontics, Dow Dental College, Dow University of Health Sciences. Period: September 2019 to January 2020. Material & Methods: This study comprised of ninety-four participants with equal number of males and females from 10 years to 70 years, visiting the Prosthodontic department. Study casts included were free of dental abnormality, trauma, malocclusion, orthodontic problems, and deformity in palatal rugae area. Sample size was calculated from software name openepi.com with 95% confidence interval. Data was tabulated and SPSS version 22.0 was used to identify the results. Results: Frequency distribution was performed among age groups in which second group (20 to 39 years) has highest frequency with 52 in number. The cross tab between age group and type of rugae was made which showed group II, having age between 20 to 39 years, had the highest number of palatal rugae configurations amongst all. Conclusion: Sinuous or type E was the predominant type of palatal rugae found in this study. The study did not show significant difference in gender, however number of rugae were found consistently more in young adults with propensity towards individuality. Their use can thus be justified for dental identification in forensic odontology.
Background Human beta defensin-3 (HβD-3) is an antimicrobial peptide present in saliva that protects tooth surfaces from microbial attack. These peptides are part of innate immunity so levels may be affected by different systemic diseases like anemia. Therefore, anemia may predispose an affected child to an increased risk of dental caries. The objectives of this study were to determine the association of early childhood caries (ECC) with HβD-3 levels and observe the association of HβD-3 levels with childhood anemia. Methods A total of 80 children admitted in a pediatric medical ward, age 48–71 months, of either sex were included in the study. The included children were categorized as cases (children with ECC n = 40) and controls (children without ECC n = 40). Children were further segregated into the anemic and non-anemic sub-groups based on the hospital record of hemoglobin level. The salivary concentration of HβD-3 was measured by Enzyme-Linked Immuno-sorbent assay (ELISA). IBM SPSS version 20 software was used for statistical analysis. Two sample t-test and one-way ANOVA were used to compare mean values while spearman was used for correlations at p < 0.05. Results The mean Salivary HβD-3 level in cases (8.87 ± 4.30) was significantly higher (p = 0.042) as compared to controls (7.23 ± 2.57). Salivary HβD-3 level in patients with caries and without anemia was highest (10.80 ± 4.50) whereas salivary HβD-3 level in the presence of caries and anemia was lowest (6.94 ± 3.13) amongst all groups. This difference was statistically significant (p = 0.001). Salivary HβD-3 level was found to be moderately correlated with cases (p = 0.002). An inverse correlation was found between salivary HβD-3 level and anemia (r = -0.479, p = 0.002). Conclusion Anemia may affect the innate immunity of children, and may result in a decreased level of salivary HβD3, thus increasing vulnerability to decay.
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