In this work, a novel compact and accurate glucose concentration measurement system is developed using the well-established photoacoustic Near Infra-Red spectroscopy. The proposed invitro instrumentation methods are in a small form factor, making it a viable candidate and precursor for an in-vivo non-invasive wearable blood glucose monitoring in the near future. The accuracy comes from the phase sensitive detection of the electrical signal. This detection technique uses an off-the shelf modulator/demodulator integrated circuit configured as a lock-in amplifier to increase the signal to noise ratio multifold. No prior work on photoacoustic spectroscopy, has taken advantage of this detection methodology in such a small form factor. The dimension of the lock-in-amplifier is 13mm x 10.65mm x 2.65mm. The maximum linear dimension of the exciting laser is 5.6 mm. The acoustic sensor (transducer) has a dimension of 42mm x 12mm. Furthermore, the measurement and analyses of the observed data uses multiple stochastic and machine learning techniques to bring out the best correlation fit between the glucose concentration and a specific feature of the electrical signal. With these methods and techniques, a strong correlation was confirmed between the glucose concentration and the amplitude of the electrical signal. The computed correlation coefficient between the signal amplitude and glucose concentration is 97% while the p-value is 5.6E-6. To the best of our knowledge, this is the first work to report photoacoustic spectroscopy for glucose concentration measurement in a compact form, with lock-in amplifier and aided with machine learning algorithms for future application as a wearable device.INDEX TERMS photoacoustic NIR spectroscopy, non-invasive glucose monitoring, lock-in-amplifier, machine learning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.