The objective was to compare the efficiency of probiotic (PT) versus antibiotic therapy (AT) as adjuvants to non-surgical-mechanical debridement (NSMD) in the treatment of peri-implant mucositis (Pi-M). Volunteers with Pi-M were encompassed. Therapeutically, patients were randomly divided into 3-groups: (a) Group-1: NSMD + PT; (b) Group-2: NSMD + AT; and (c) Group-3: NSMD alone. Peri-implant plaque index (P.I), bleeding on probing (B.O.P), probing depth (P.D) and crestal-bone-loss (C.B.L) were recorded at baseline and at 3-and 6-months follow-up. P<0.05 was selected as the indicator of statistical significance. Forty-two male individuals (14, 14 and 14 in groups 1, 2 and 3, respectively) were included. At 3- and 6-months of follow-up, P.I (P<0.01), B.O.P (P<0.01) and P.D (P<0.01) were higher in Group-2 than Group-1. At 3-months of follow-up, P.I (P<0.01), B.O.P (P<0.01) and P.D (P<0.01) were higher in Group-3 than Group-2. At 6-months of follow-up, P.I, B.O.P and P.D were comparable in groups 2 and 3. In Group-3, P.I, B.O.P and P.D were comparable with the respective baseline values at 6-months of follow-up. The C.B.L in all groups remained unchanged up to 6-months of follow-up. The NSMD with adjuvant PT is more effective than adjunct AT in the treatment of Pi-M for up to 3-months.

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Background The aim of this study was to evaluate the effect of universal adhesives (UA) and silane on the microtensile bond strength (μTBS) of resin cement to a hybrid ceramic Vita Enamic (VE). Methods VE specimens were acid etched using hydrofluoric acid (HF) and were assigned to three groups ( n = 10) based on the applied bonding technique. In group 1 (S), a silane-based primer was used as a surface treatment prior to the application of a resin cement (Variolink Esthetic DC). In group 2, a silane-containing UA, Clearfil Universal Bond (CUB) was used for the surface treatment, and in group 3, A silane-free UA, Tetric N-Bond Universal (TNU) was used for surface treatment. Resin cement build-ups were prepared. The bonded specimens were sectioned into resin-ceramic beams. Half of the beams of each group were stored for 24 h at 37 °C and the other half were subjected to a thermo-cycling aging. The microtensile bond strength (μTBS) was measured at a crosshead speed of 0.5 mm/min. Failure modes were assessed accordingly. Data were analyzed using a) two-way analysis of variance ANOVA followed by one-way ANOVA and Tukey tests between groups and b) independent t- test to detect differences (α = 0.05) for each group. The surface topographies of the ceramic surface were evaluated using scanning electron microscopy. Results The results showed that silane-based primer (S) application resulted in significantly higher (p < 0.05) μTBS values after 24 h and after thermocycling compared to both silane-containing UA (CUB) and silane-free UA (TNU). The μTBS values of all groups were significantly reduced after thermocycling. No statistically significant difference was observed between the μTBS of CUB and TNU after 24 h. However, TNU showed significantly higher μTBS after thermocycling. Different failure modes were observed, and adhesive failure was the most common in all groups. Marked surface topographic changes were observed following HF etching. Conclusion It is concluded that, the UAs tested cannot be recommended as substitutes to the silanization of Hybrid ceramic.

Background It is hypothesized that in the long‐term, (a) peri‐implant inflammatory variables (plaque index [PI], bleeding on probing [BOP], probing depth (PD) and crestal bone loss [CBL]) are worse in cigarette‐smokers (CS) and patients with type‐2 diabetes mellitus (T2DM) than never‐smokers (NS) without T2DM. The aim of the present 7‐year follow‐up clinical observational study was to assess the survival of dental implant in CS and NS with T2DM. Methods Study participants were divided into four groups based on glycemic status and self‐reported cigarette‐smoking habit: a) CS with T2DM; b) CS without T2DM; c) NS with T2DM; and d) NS without T2DM. Demographic information was collected using a questionnaire and hemoglobin A1c (HbA1c) levels were measured. Peri‐implant PI, BOP, PD, and CBL were measured. Sample‐size was estimated was statistical analysis was done using analysis of variance. P <0.01 was considered significant. Results In total, 101 male patients were included. There was no significant contrast in age among the groups. Every partaker in the study groups had one dental implant placed in posterior maxilla or mandible. The mean HbA1c levels were significantly higher among CS (P <0.01) and NS (P <0.01) with T2DM than individuals without T2DM. Peri‐implant PI (P <0.01), PD (P <0.01), and CBL (P <0.01) were significantly higher among CS and NS with T2DM and CS without T2DM than NS without T2DM. Peri‐implant BOP was significantly higher among CS and NS with T2DM than CS and NS without T2DM (P <0.01). Conclusions Peri‐implant inflammatory variables were worse among CS and NS with T2DM than NS without T2DM. A state of chronic hyperglycemia seems to be a stronger mediator of inflammation than cigarette smoking in patients with T2DM.

The aim of this study was to evaluate the properties of new dental formulations containing eugenyl-2-hydroxypropyl methacrylate (EgGMA) monomer, as restorative dental material, in terms of their degree of photopolymerization and cytotoxicity. The target model composites (TBEg0, TBEg2.5, and TBEg5) were prepared by mixing 35% organic matrix (TEGDMA/BisGMA (50/50 wt%) of which 0, 2.5, and 5 wt%, respectively, were replaced with EgGMA monomer) with 65% filler (silanized hydroxyapatite (HA)/zinc oxide (ZnO2), 4:3 by weight). The vinylic double-bond conversion (DC) after light-curing was studied using Fourier transform infrared technique whereas cell viability was in vitro tested using primary human gingival fibroblasts cells over 7 days by means of AlamarBlue colorimetric assay. The obtained data were statistically analyzed using ANOVA and Tukey post-hoc tests. The results revealed no significant difference in DC between TBEg2.5 (66.49%) and control (TBEg0; 68.74%), whereas both differ significantly with TBEg5, likely due to the inhibitory effect of eugenol moiety at high concentration. The cell viability test indicated that all the composites are biocompatible. No significant difference was counted between TBEg2.5 and TBEg5, however, both differed significantly from the control (TBEg0). Thus, even though its apparent negative effect on polymerization, EgGMA is potentially safer than bisphenol-derived monomers. Such potential properties may encourage further investigations on term of EgGMA amount optimization, compatibility with other dental resins, and antimicrobial activity.

We hypothesized that in the long-term (6-months follow-up), non-surgical mechanical debridement (NSMD) with adjunct low-level laser therapy (LLLT) is more effective for the treatment of peri-implantitis compared with NSMD alone. The aim of the present 6-months follow-up convenience-sampled cohort study was to assess the efficacy of LLLT as an adjunct to NSMD in the treatment of peri-implantitis. A questionnaire was used to collect demographic information. Patients with peri-implantitis in the test-and control groups underwent NSMD with and without adjunct LLLT, respectively. Randomization was done by tossing a coin. In the test group, the laser was applied perpendicularly to the periodontal pocket for 20 seconds at a constant distance of 15 mm and with a continuous wavelength (3.41 J/cm2 delivery with a 1.76 cm2 spot and average output of 0.3 W). In both groups, peri-implant probing depth, bleeding upon probing and crestal bone resorption were assessed at baseline and at 3- and 6-months’ follow-up. Group comparisons were performed and P&lt;0.05 was considered statistically significant. Sixty-seven individuals with peri-implantitis were included. The mean age of individuals that underwent NSMD with adjunct LLLT and NSMD alone 46.5±3.4 and 45.3±1.1 years, respectively. At 3 and 6-months’ follow-up, peri-implant PI (P&lt;0.05), BUP (P&lt;0.05) and PrD (P&lt;0.05) were significantly higher among patients that underwent NSMD alone compared with individuals that underwent NSMD with adjunct LLLT. There was no significant difference in CBR in all patients up to 6-months’ follow-up. In the short-term, NSMD with adjunct LLLT is a useful treatment protocol for the treatment of peri-implant soft-tissue inflammation.

BackgroundThe hypothesis is that self‐rated peri‐implant oral symptoms (OS) and clinical (plaque index [PI] and probing depth [PD]) and radiographic (crestal bone loss [CBL]) are higher in (cigarette‐smokers [CS]) and (waterpipe‐users) than (nonsmokers [NS]). The aim was to relate peri‐implant self‐perceived OS with clinico‐radiographic parameters among CS, waterpipe‐users, and NS.Materials and MethodsThis study was performed on self‐reported CS, waterpipe‐users, and NS with peri‐implantitis. A questionnaire was used to record peri‐implant self‐perceived OS (pain in gums, bleeding gums, bad breath, and loose implant) and demographic data (age, sex, duration of smoking and waterpipe usage, duration of implants in function, duration since diagnosis of peri‐implantitis). Clinico‐radiographic parameters (CBL, PD, PI, and bleeding on probing [BOP]) were also measured; and compared with the self‐perceived OS. Group comparisons were done for perceived OS and clinico‐radiographic variables, and significant differences were deemed when P‐values were under .05.ResultsOne hundred male participants (35 CS, 33 waterpipe‐users, and 32 NS) with peri‐implantitis were included. Pain in gums (P < .05) and bad breath (P < .05) were more frequently perceived by CS and waterpipe‐users than NS. There was no significant difference in perceived bleeding gums around the implant or loose implant among all groups. The CBL (P < .01), PI (P < .001), and PD (P < .01) were significantly high in CS and waterpipe‐users than NS. NS (P < .05) had significantly higher BOP than waterpipe‐users and CS. There was no significant difference in CBL, PI, PD, and BOP among waterpipe‐users and CS.ConclusionTobacco‐smokers present with worse peri‐implant perceived OS and clinicoradiograhic parameters than nonsmokers with peri‐implantitis.

The present study aimed to evaluate the properties of new dental formulations incorporating a new polymerizable-derivative of eugenol (EgGMA). The experimental composites were prepared (by weight) with 35% resin-based matrix (1:1, bisphenol A-glycidyl methacrylate/triethylene glycol dimethacrylate) and 65% reinforcing materials (4:3, hydroxyapatite/zirconium oxide). A portion of 0.0, 2.5, and 5.0% of the resins with respect to the total composite was replaced by EgGMA monomer to obtain TBEg0, TBEg2.5, and TBEg5, respectively. The complex viscosity (at 25 and 37 °C), degree of conversion (DC), and water sorption (WSP) and water solubility (WSL) (3 cycles of sorption-desorption process) were investigated. Data were statistically analyzed using one-way and Tukey post-hoc tests. The results revealed a viscosity reduction with shear-thinning behavior as the EgGMA amount and temperature increased. The average complex viscosities at a lower frequency (ω = 1.0 rad/s) and at 25 °C were 234.7 ± 13.4, 86.4 ± 16.5, and 57.3 ± 17.1 (kPa·s) for TBEg0, TBEg2.5, and TBEg5, respectively. The inclusion of EgGMA led to a lower DC and WSP but higher WSL, compared to those of the reference (TBEg0). However, no significant differences between TBEg2.5 and control were detected (p > 0.05). Therefore, the incorporation of EgGMA in a low quantity, e.g., up to 8.45 mol% of resins, within the matrix may enhance the composite’s performance, including handling and solubility properties without any apparent effect on DC and water sorption, making it a promising monomeric biomaterial for various applications including restorative dentistry.