Objective To determine whether the Greulich and Pyle (G&P) atlas is applicable when applied to populations of different ethnicity. Methods A systematic review of studies published between 1959 and 15th February 2017 identified from the Embase, MEDLINE and Cochrane databases was undertaken. Quality of the studies was assessed using the National Institute for Health and Care Excellence tool. Meta-analysis used mean differences and standard deviations as summary statistics for the difference between bone age (BA) and chronological age (CA). Results A total of 49 studies were included of which 27 (55%) were related to Caucasian populations. Of the 49 eligible studies, 35 were appropriate for further meta-analysis. In African females, meta-analysis showed a significant mean difference between BA and CA of 0.37 years (95% CI 0.04, 0.69). In Asian males, meta-analysis showed significant differences between BA and CA of -1.08, -1.35, -1.07, -0.80 and 0.50 years for chronological ages of 6, 7, 8, 9 and 17 years, respectively. Meta-analysis showed no significant differences between BA and CA in African males, Asian females, Caucasians and Hispanics. Conclusions The G&P standard is imprecise and should be used with caution when applied to Asian male and African female populations, particularly when aiming to determine chronological age for forensic/legal purposes. Key Points • In African females, bone age is significantly advanced when compared to the G&P standard. • In Asian males, bone age is significantly delayed between 6 and 9 years old inclusive and significantly advanced at 17 years old when compared to the G&P standard. • The G&P atlas should be used with caution when applied to Asian and African populations, particularly when aiming to determine chronological age for forensic/legal purposes. Electronic supplementary material The online version of this article (10.1007/s00330-018-5792-5) contains supplementary material, which is available to authorized users.

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This paper deals with the principal aspects emerging from the application of trust techniques to the IoT domains with respect to the particular viewpoint of an IoT environment. We consider intelligent agents technology to add social behavior to the community of the smart objects, and we analyze the fundamental role of the concepts of trust and reputation in this perspective. Also, we analyze the existing architectures for IoT and explain how to integrate IoT with fog/edge computing. Besides discussing the main proposals present in the literature, the key contribution of this paper consists of providing a comparative study of the main current architectures for modeling trust in IoT environments. In this setting, we propose a comparison based on the important characteristics of the IoT layer and the architecture type. Such an analysis allows us to highlight both advantages and limitations of each approach, and to discuss the emerging research challenges. INDEX TERMS Internet of Things, multi-agent system, reputation, trust, edge/fog computing.

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This is a repository copy of Evaluation of a semi-automated software program for the identification of vertebral fractures in children..