Background:The sigma-1 receptor modulates the function of numerous ion channels. Results: We studied the interaction between the sigma-1 receptor and hERG.
Conclusion:The interaction has a 4:1 stoichiometry and occurs at the plasma membrane. Significance: The sigma-1 receptor may bind to hERG in the endoplasmic reticulum, aiding its assembly and trafficking to the plasma membrane.
Phthalimido-alkanol solid supports were rapidly prepared from solid supported phthalic anhydride and amino alcohol condensation induced by microwaves. These supports were used to synthesize 5'-fluorescent 3'-aminoalkyl oligodeoxynucleotides allowing a two-step deprotection necessary to avoid aminolink alkylation. After conversion into an NHS derivative using dissuccinimidyl suberate and an optimized isolation, they were conjugated with a protein.
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