No abstract

ARTIcLE INFO _________________________________________________________ ___________________Objective: This study was developed to determine whether the generation of free radicals, induced by ischemia followed by reperfusion in a model of chronic intravesical obstruction in rats, would lead to damage in the detrusor. It also investigates the possible protective action of the flavonoid galangin on the tissue lesion induced by lipid peroxidation. Materials and Methods: Twenty-one male rats were divided into three groups of seven animals each. Group A was subjected to a sham procedure; group B to partial obstruction of the bladder neck; and group C to partial obstruction of the bladder neck, but also received a diet rich in the flavonoid galangin. All the animals were subjected to urodynamic evaluation and then sacrificed. The bladders were sent for enzymatic tests. Results:The urodynamic showed that group B developed significantly greater numbers of involuntary contractions of the detrusor, greater post-micturition residue and lower compliance. The group A presented TEAC levels greater than to the group B. Comparative analysis of group A, B and C demonstrated significantly greater malondialdehyde levels in group B in relation to groups A and C. The group B presented smaller contraction amplitudes than did groups A and C, in electrically stimulated contractions. Conclusions: That oxidative stress is implicated in the damage to the detrusor musculature following a period of chronic intravesical obstruction. We show, for the first time, that administration of an antioxidant prior to and following the start of chronic obstruction makes it possible to avoid the cellular lesions that cause detrusor dysfunction.

There is a statistically association between DM and LUTS on Elder men, evaluated through a specific questionnaire.

Mesial temporal lobe epilepsy (MTLE) is frequently associated with mesial temporal sclerosis 1 , 2 which can be identified by magnetic resonance imaging (MRI) as hippocampal atrophy usually associated with abnormal T2 hyperintense signal and other abnormalities in the mesial temporal lobe structures. 3 -5 Pathological and MRI studies in surgical series of patients with ABSTRACT: Background/Objective: Diffuse temporal lobe abnormalities can be observed on MRI of patients with mesial temporal lobe epilepsy (MTLE). Our objective was to perform qualitative and quantitative analyses of temporal lobe structures in patients with familial MTLE (FMTLE) and nonfamilial MTLE. Methods: Two groups of patients were ascertained: 67 FMTLE patients (14 with refractory seizures) and 30 patients with nonfamilial refractory MTLE. We performed qualitative analyses of MRI (with multiplanar reconstruction) and volumes of hippocampi and anterior temporal lobes in all patients, and in a normal control group of 23 individuals. We used the Chi-square test and ANOVA for statistical analyses. Results: We identified anterior temporal lobe abnormalities by visual analysis in only 4% of FMTLE patients and atrophy of the anterior temporal lobe by volumetric analysis in 19%. In the group of nonfamilial MTLE patients we found anterior temporal lobe abnormalities by visual analysis in 17% of patients and anterior temporal lobe atrophy in 13%. Hippocampal atrophy was present in 90% of FMTLE and in 83% of nonfamilial MTLE. No signs of cortical dysplasia were observed. Conclusion: Anterior temporal lobe atrophy and other abnormalities outside the mesial portion of temporal lobes were infrequent in both familial and nonfamilial MTLE patients. Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions. Nous avons utilisé le test du c2 et l'ANOVA comme analyses statistiques. Résultats: Nous avons identifié des anomalies du lobe temporal antérieur par analyse visuelle chez seulement 4 % des patients atteints d'ÉLTMF et une atrophie du lobe temporal antérieur par analyse volumétrique chez 19 % de ces patients. Dans le groupe de patients atteints d'ÉLTM non familiale, nous avons observé des anomalies du lobe temporal antérieur par analyse visuelle chez 17 % des patients et une atrophie du lobe temporal antérieur chez 13 %. Une atrophie de l'hippocampe était présente chez 90 % des patients atteints d'ÉLTMF et chez 83 % des patients atteints de la forme non familiale. Aucun signe de dysplasie corticale n'a été observé. Conclusion: Une atrophie du lobe temporal antérieur et d'autres anomalies ne touchant pas la partie mésiale des lobes temporaux étaient rares tant chez les cas familiaux que chez les cas non familiaux. Malgré son étiologie génétique, l'atrophie de l'hippocampe n'est pas associée à des anomalies de structures en dehors des régions temporales mésiales dans l'ÉLTMF.

Erectile dysfunction develops among 46.2% of men between 40 and 70 years. Studies demonstrated substitution on detrusor muscle by collagen due testosterone deprivation. It is clear the correlation among aging and oxidative stress, accelerating apoptosis process in many tissues. This study aims to demonstrate the collagen substitution over the muscle fibers on muscle structure of rat's penis and the effects of testosterone supplementation. Sixteen senescent Wistar rats were divided into two groups: treatment (receiving standard supplementation testosterone dose) and control (receiving equivalent saline solution). Testosterone was dosed on D0 and D56 of study. All penises were prepared with picrosirius colored histology; stereology was applied to determine the volumetric density of collagen fibers (Vv). Analysis of variance demonstrated testosterone group's replacement therapy to be effective, while the androgenic decline continued by the time of experiment in control group (p < 0.05). Testosterone group had Vv of 20.6%, lower than control group (47.8%); t-test (p < 0.001). Pearson's correlation demonstrated an inverse correlation between the Vv and testosterone's levels (p < 0.001). This is a pioneer study on demonstration of structural alterations over the cavernous corpora muscle caused by deprivation of testosterone on elderly rat. These finding implicate that the testosterone levels can influence, not only the libido, but also the erectile function.