Autores e colaboradores Diretrizes para Cessação do Tabagismo Número de substâncias identificadas em 15 funções químicas existentes no fumo Funções Número de químicas substâncias Amidas, imidas 237 Ácidos carboxílicos 227 Lactonas 150 Ésteres 474 Aldeídos 108 Cetonas 521 Álcoois 379 Fenóis 282 Aminas 196 N-eterocíclicos 921 Hidrocarbonetos 755 Nitrilas 106 Éteres 311 Carboidratos 42 Anidridos 11 Total 4.720

Smoking behavior is influenced by genetic factors. Polymorphisms affecting the dopaminergic system have been linked to smoking habits. The aim of this study was to investigate if the T102C polymorphism of the 5-HT(2A) receptor gene is related to tobacco use, since this receptor modulates the mesolimbic dopamine system and the C allele is associated with reduced receptor gene expression. A sample of 625 subjects were genotyped and classified according to their smoking behavior (never, former, or current smokers). We found differences in the distribution of the genotypes when the current smokers were compared with the never + former smokers, suggesting that T102C polymorphism is associated with maintenance, but not with initiation of the smoking habit. The CC genotype was more frequent in the current smokers than in the never + former smokers (chi(2) = 6.825, P = 0.03). The odds ratio of being a current smoker with a CC genotype was 1.63, 95% CI 1.06-2.51.

The higher percentage of smoking cessation was achieved using multiple therapies (counseling + NRT + bupropion). The only significant predictor of failure detected was severe nicotine dependence.

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