Advances in the synthesis of acylpyridines, pyridinecarboxylic acids, and their derivatives involving direct functionatization of the pyridine ring and substituent modification over the past 15 years are reviewed.The present review is the second part of a series of reviews on the functionalization of the pyridine ring. In this part, we review the preparation of acylpyridines, pyridinecarboxylic acids, and their derivatives involving both functionalization of the pyridine ring and modification of ring substituents. We should note the general nature of most of the methods examined for the preparation of the various pyridine derivatives containing a wide range of substituents in addition to the indicated functional groups. The limitations of these methods will be noted in each individual case.
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