Functionalization of pyridines. 2. Synthesis of acylpyridines, pyridinecarboxylic acids, and their derivatives. Review

Abstract

Advances in the synthesis of acylpyridines, pyridinecarboxylic acids, and their derivatives involving direct functionatization of the pyridine ring and substituent modification over the past 15 years are reviewed.The present review is the second part of a series of reviews on the functionalization of the pyridine ring. In this part, we review the preparation of acylpyridines, pyridinecarboxylic acids, and their derivatives involving both functionalization of the pyridine ring and modification of ring substituents. We should note the general nature of most of the methods examined for the preparation of the various pyridine derivatives containing a wide range of substituents in addition to the indicated functional groups. The limitations of these methods will be noted in each individual case.

Selective Decarboxylation: A Facile Synthesis of 3-Pyridinecarboxylic Acid Derivative

“…[1,2] As a fluorine-containing derivative of 3-pyridinecarboxylic acid, 5-trifluoromethyl-3-pyridinecarboxylic acid 1 is a useful synthon, in particular for medicinal chemistry. [3][4][5][6] Only two multistep synthetic routes to compound 1 have been reported.…”

Iron(II) Complexes of Chiral Tridentate Nitrogen Donors and their Application in Catalytic Hydrosilylation Reactions

“…Compared to ruthenium(II) compounds, typical iron(II) complexes are kinetically less stable. Therefore multidentate ligands such as the above‐mentioned P,N,N,P systems or terpyridine ligands are requested to guarantee a minimum of structural stability. However, it is difficult to achieve a broad variety of structurally closely related donors from tridentate N,N,N ligands like terpyridines since pyridines are deactivated aromatic systems and thus not prone for example to electrophilic substitution.…”