The psychotropically active principles of the Mexican hallucinogenic fungus Psilocybe maxicana HEIM have been isolated and obtained in crystalline form. The two new substances, which have been called psilocybin and psilocin, are present in the fruit bodies, the artificially cultivated mycelium and in the sclerotia. The dried mushroom contains 0.2 to 0.4 per cent psilocybin. Psilocin is present, at the most, in trace amounts only.
Es wird eine rationelle Synthese für das Bufotenin und andere ω‐N‐substituierte 5‐Oxy‐tryptamine angegeben. Folgende neue Verbindungen aus der Reihe der Oxy‐tryptamine werden beschrieben: 5‐Oxy‐ω‐N‐methyl‐tryptamin, 5‐Oxy‐ω‐N‐äthyl‐tryptamin, 5‐Oxy‐ω‐N, N‐diäthyl‐tryptamin, 5‐Oxy‐ω‐N‐β‐aminoäthyl‐tryptamin, N‐[β‐(5‐Oxy‐indolyl‐(3))‐äthyl]‐piperidin, sowie zwei Stellungsisomere des Serotonins, das 4‐Oxy‐tryptamin und das 6‐Oxy‐tryptamin.
An iodine-labeled beta-adrenergic inhibitor ((125)l-hydroxybenzylpindolol) binds specifically to a site on turkey erythrocyte membranes. A series of beta-adrenergic agonists and inhibitors compete for this binding site, with apparent affinities paralleling biological effectiveness as activators or inhibitors of catecholaminestimulated adenylate cyclase. The activity of d-(+) agonists or inhibitors was 1 percent (or less) than that of the corresponding l-(-) isomers in competing for binding of the iodinated blocker as well as in affecting catecholamine-stimulated adenylate cyclase. 1-(-)-Norepinephrine was about one-tenth as active as l-(-)-isoproterenol in competing for the beta-blocking agent site. The stereospecificity of the interaction with the iodinated beta-blocking agent and the correspondence between affinity for site and biological potency of analogs suggested that this interaction is involved in function of the beta-adrenergic receptor.
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