Konstitutionsaufklärung und Synthese von Psilocybin

Classic hallucinogens in the treatment of addictions

“…Following Albert Hoffman's accidental discovery of the psychoactive effects of LSD in 1943 (Hofmann, 1979) and isolation and synthesis of psilocybin in 1958 (Hofmann et al, 1958a;Hofmann et al, 1958b), the 1950s through the early 1970s saw an explosion or research on classic hallucinogens. Clinicians and clinical scientists explored the use of classic hallucinogens to facilitate rapid therapeutic effects in alcohol and drug addiction, as well as anxiety, depression, obsessive-compulsive disorder, and other conditions.…”

Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin

“…These data focus on the possibility that, if the schizophrenias are produced by a disturbance in biochemical mechanisms analogous to that resulting from the administration of mescaline, LSD and similar substances, comparatively nontoxic molecules might be administered therapeutically to produce tolerance to the endogenous chemicals that might originate schizophrenic states. In accordance with this concept, developed mathematically with Gorin (.3), our present studies on cross-tolerance have been conducted not only using lysergic acid derivatives, but also employing a new psychotomimetic compound recently synthesized by Hofmann (8). Thus, LSD and Psilocybin in the fish may affect the same enzyme systems as do the respiratory enzyme poisons (6, 10).…”

Champignons hallucinogènes d'Europe et des Amériques : mise au point mycologique et toxicologique

“…Les principes actifs des champignons hallucinogènes sont des dérivés indoliques : la psilocybine (4-phosphoryloxy-N, V-diméthyltryptamine), qui est le plus important, et la psilocine (4-hydroxy-N, V-diméthyltryptami-ne). Hofmann les a isolé et identifié dans le Psilocybe semilanceata, puis les a synthétisé (36,37). Leurs structures sont représentées Figure 1.…”

“…Dos. : psilocybine et psilocine (Hofmann et al, 1958 ;Heim & Wasson, 1958 ;Heim et al, 1958 ;Hofmann & Troxler, 1959 ;Hofmann et al, 1959 Écol. : sur débris ligneux dans l'herbe ou dans les fourrés rudéralisés, souvent dans les lieux perturbés par l'activité humaine.…”