The syntheses of different 9‐(N‐phthalyl‐ or N‐tosyl‐ or free aminoacyl)carbazoles and the corresponding derivatives of 3,6‐dinitrocarbazoles and some derivatives of 3,6‐diamino‐9‐(N‐phthalylaminoacyl)carbazoles (II‐XXXII) are described. Compounds VIII, XIII‐XVII and XXIII‐XXVII were found to be active against a number of microorganisms.
A new series of transition metal complexes have been synthesized with [(2,3-dimethylphenyl)amino]benzoic acid (Mefenamic acid) in 1 : 1/1 : 2 M : L ratio. The complexes have been characterized by elemental analysis, FT-IR and UV-Vis spectroscopy. Antifungal, antibacterial, antitumor, antioxidant (DPPH, H 2 O 2 induced DNA damage) activity of the complexes and DNA interaction with the complexes were studied. The results revealed that the ligand and most of synthesized compounds did not demonstrate significant antibacterial activity unlike [Ni(Mef)(H 2 O)Cl] that exhibited pronounced activity against F. Solani. Antitumor activity of the products was higher than that of the free ligand.
Durch Umsetzung der Säurechloride (I) bzw. (V) mit entsprechenden Aminosäureester‐hydrochloriden (II) werden die Verbindungen (III) bzw. (VI) synthetisiert, die auf ihre pharmakologischen Eigenschaften getestet werden sollen.
The synthesis of 6-nitrocouarmin-3-CO-amino acids and their corresponding methyl esters (11-XVII) and some dipeptide methyl esters (XVIII-XXVI) are described. B-(N-Tosyl-or N-phthalylaminoacy1)aminocoumarin-3-carboxylic acid methyl esters (XXXIV-XL) and 3-(N-phthalylor N-tosylaminoacy1)arninocoumarins (XLV-LVI) have been prepared via the carbodiimide and acid chloride methods. Hydrazinolysis of 3or 6-(N-phthalylaminoacyl)aminocoumarin derivatives in tetraline gave the corresponding 3-and 6{aminoacyl)aminocoumarins and the carboxylic acid hydrazides (XLI-LVIII), respectively. 3-(N-Tosyl-L-Val-L-Leu-)aminocoumarin (LIX) was synthesized via the azide method. Twenty four of various substituted 3-and 6-aminoacylcoumarin derivatives were found to possess specific antimicrobial activities towards different microorganisms.
Glycyrrhetinsäurechlorid (Ia) reagiert beim Erhitzen mit Glycinmethylesterhydrochlorid in Dioxan in Gegenwart von Triäthylamin unter Bildung von Glycyrrhetylglycin‐methylester (Ib).
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