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Four medulloblastomas were studied cytogenetically with clinical follow-up of the patients. Three of these lesions were diploid and the patients manifested no recurrence at 40, 37 and 36 months respectively. The remaining tumor was aneuploid with 52 chromosomes and the patient expired of the medulloblastoma in 7 months. These findings are compared to nine previously reported karyotypes of primary medulloblastomas only two of which had clinical follow-up of the patients. On the basis of our results and these previously reported cases it appears that medulloblastomas with a diploid chromosomal pattern have a better prognosis than those with aneuploidy.

Abslract. The response of the cranial vault to bilateral parasagittal craniectomies in the treatment of sagittal synostosis is described. Silicone film is used to cover the bony margins of the defect. Maximum expansion of the cranial vault at the defect occurs within 3 months. During the healing process, the margin of the skull within the silicone cuff is resorbed while new bone is formed in the defect, ultimately bridging the defect. The radiographic picture has been uniform in three patients.