The
complex reconstructive surgeries for which patient-specific
orthopedic, maxillofacial, or dental implants are used often necessitate
wounds that are open for a considerable amount of time. Unsurprisingly,
this allows bacteria to establish implant-associated infection, despite
the scrupulous sterilization efforts made during surgery. Here, we
developed a prophylactic bactericidal coating via electrophoretic
deposition technology for two 3D-printed porous titanium implant designs.
The surface characteristics, antibiotic release behavior, antibacterial
properties, and impact on osteoblast cell proliferation of the optimized
coatings were investigated. The results unequivocally confirmed the
biofunctionality of the implants in vitro. This study reveals a new
avenue for future antibacterial patient-specific implants.
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