First, patients with essential hypertension are characterized by higher plasma leptin levels as compared with normotensive healthy subjects; second, suppressive effect of pindolol on leptinemia may be of pathophysiological relevance in the course of weight gain during beta-blocker therapy.

Summary: γ-glutamyl transpeptidase of human serum studied by starch gel electrophoresis and Sephadex filtration is not homogenous. Excepting liver cirrhosis no distinct distribution pattern of activity specific to any hepatobiliary disease or other internal diseases were found. Studies of GGTP heterogeneity seems to be of no great clinical significance in the differential diagnosis of hepatic or extrahepatic diseases.

Tamm-Horsfall protein (THP) is a glycoprotein that is

The morphometric investigation of the proximal and distal tubules, the cortical interstitium, the inter-tubular capillaries, the renal corpuscles and the juxtaglomerular apparatuses (JGAs) in 56 cases in the oligoanuric, polyuric, and normuric phases of human acute renal failure (ARF), 6 cases of myeloma kidney with clinically confirmed ARF and 21 control kidneys revealed the following: (1) The main pathological change in human ARF is swelling of the epithelial cells of the proximal and distal tubules. Necrosis of these cells was observed in some cases but usually only as single cell necroses. (2) The interstitium of the cortex and of the outer stripe of the outer medulla is significantly widened in most cases of ARF. (3) In proximal tubules proximal to occluding casts (which were observed only in the plasmacytoma cases), the lumina are not widened but are narrower than normal, and the cross-sectional area of the epithelium is not greater but smaller than normal. (4) The JGAs were significantly larger in kidneys in the oligoanuric phase of ARF (with 1 exception) than in normal kidneys. In the normuric and polyuric phases they were slightly (not significantly) smaller than normal. In myeloma kidneys with occluding casts and/or diffuse interstitial fibrosis, the JGAs were significantly smaller than normal. From these findings it is concluded that: (1) The fall in glomerular filtration rate (GFR) in the postshock phase of ARF is not caused by nonselective back-diffusion of the primary urine through necrotic tubules or by compression of the lumina of the proximal and distal tubules by interstitial edema. A fall in GFR associated with occluding casts in the distal tubules is found only in the myeloma kidney and does not lead to widening of the proximal tubules but to tubular atrophy and narrowing of the lumen. (2) The casts seen in the lumina of the ascending limb of Henle’s loop in some cases of ARF, which consist of hemoglobin, Tamm-Horsfall protein or desquamated blebs, do not occlude the lumen, since they are not associated with atrophy or luminal dilatation of the proximal tubules. (3) The JGAs with their secretory product renin-angiotensin II, together with adenosine, which is released in kidneys with ischemic or toxic damage, play a critical role in the pathogenesis of ARF. (4) In myeloma kidneys with ARF, in which the JGAs are markedly atrophic, the potentiated effect of adenosine that has been observed with a chronic absence of urine flow probably leads to a progressive, irreversible drop in GFR associated with tubular atrophy.

As altered lipid metabolism was reported in patients with chronic renal failure, it was of value to establish the effect of fat loading on the concentration of total cholesterol (Ch), total fatty acids (TFA), β-lipoproteins (β-LP), triglycerides (TG) and free fatty acids (FFA) in serum. 194 patients with various renal diseases were examined. Abnormality in lipid handling was found not on y in uremic patients, but also in renal patients with unimpaired excretory kidney function. This abnormality was especially expressed in high fasting plasma levels of β-LP and TG in compensated pyelonephritic patients and in abnormal rise of these lipid fractions after ingestion of a fat meal. Lipid handling by compensated pyelonephritic patients was pathologically changed compared with glomerulonephritic subjects which seemed to indicate that the renal medulla might be connected with the lipid metabolism.