Effects of Fat Load on Serum Lipids in Patients with Renal Disease

Abstract

As altered lipid metabolism was reported in patients with chronic renal failure, it was of value to establish the effect of fat loading on the concentration of total cholesterol (Ch), total fatty acids (TFA), β-lipoproteins (β-LP), triglycerides (TG) and free fatty acids (FFA) in serum. 194 patients with various renal diseases were examined. Abnormality in lipid handling was found not on y in uremic patients, but also in renal patients with unimpaired excretory kidney function. This abnormality was especially expressed in high fasting plasma levels of β-LP and TG in compensated pyelonephritic patients and in abnormal rise of these lipid fractions after ingestion of a fat meal. Lipid handling by compensated pyelonephritic patients was pathologically changed compared with glomerulonephritic subjects which seemed to indicate that the renal medulla might be connected with the lipid metabolism.

Hypercholesterolaemia and Hypertriglyceridaemia in Patients with Analgesic Nephropathy

“…Kokot el al. [29] reported higher triglyceride concentra tions in the plasma after an experimental fat load in pa tients with compensated pyelonephritis than in patients with glomerulonephritis. They postulated the deficiency of a so-called 'fat lowering factor' in patients with pyelo nephritis and a predominant destruction of the renal me dulla.…”

Serum Glucose, Insulin, Growth Hormone, Free Fatty Acids and Lipids Responses to High Carbohydrate and to High Fat Isocaloric Diets in Patients with Chronic, Non-nephrotic Renal Failure

“…Hypertriglyceridemia appears to be associated also in chronic renal failure with elevated insulin levels and abnormal glucose tolerance, as weil known from studies on non-uremic subjects (Farquhar et al 1966, Reaven et al 1967, Bierman and Porte 1968, Ford, Bozian and Knowles 1968, Glueck, Levy and Frederickson 1969, Bagdade, Bierman and Porte 1971. Moreover, hypertriglyceridemia in chronic renal failure is not only the effect of hyperinsulinism but also of an impaired triglyceride removal from plasma (Bagdade, Porte and Bierman 1968, Kokot et al 1971, Gutman et al 1973. The results obtained in our uremies after the diet trial confirm both pathogenetic mechanisms, because the enhancement of triglyceride synthesis resulted in the uremies of the groups A and B in presence of significantly higher insulin levels than in group C, in which triglyceride conversion was of minor degree or absent at all, and because in 9 of our 16 uremies the serum triglyceride levels did not return after the CH period the the pre-trial levels.…”

Das elektrophoretische Muster der γ-Glutamyltransferase im Serum und seine Änderung durch Chylomikronen

“…Unsere Ergebnisse stimmen mit den bisherigen Publikationen (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) Glutamat-Oxalat-Transaminase (EC 2.6.1.1) und Glutamat-Pyruvat-Transaminase (EC 2.6.1.2).…”

“…Kokot &Kuska (18,19) gelang es 1965 erstmals nachzuweisen, daß es elektrophoretisch trennbare Formen der -Glutamyltransferase gibt. Seitdem wurde die Trennung der y^GiutamyltTznsfeiase in multiple Formen mit Hilfe verschiedener Trägermaterialien mehrfach wiederholt (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

“…Seitdem wurde die Trennung der y^GiutamyltTznsfeiase in multiple Formen mit Hilfe verschiedener Trägermaterialien mehrfach wiederholt (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). Wenn auch die bisher publizierten "Isoenzymmuster" völlig unterschiedlich und nicht vergleichbar waren, so haben die meisten Autoren doch ihren jeweiligen "Enzymmustern" eine diagnostische oder prognostische Aussage entnehmen können.…”