Alterations in leptin, NPY and a-MSH are frequently observed in obesity and might stimulate SNS activity, contributing to the development of hypertension in obese patients. These neuropeptides might provide a pathophysiologic link between excess weight and hypertension. However, more research is needed before the pharmacologic manipulation of these complex neuroendocrine systems can be applied in the treatment of obesity and hypertension.
care services, the older inhabitants of islands were found to have a higher level of the successful aging index when compared to their counterparts in Mani (Beta¼0.174, p<0.001). Engaging in physical activities and healthy dietary habits were the major determinants of healthy aging, among islanders as compared to their counterparts of continental Mani region. Moreover, islanders exhibited a similar year-average of "good" health as compared with Mani residents (68.7 vs 68.4 years, (p¼0.99)). However, compared to the residents of Mani, islanders had 1.64 times higher odds (95%CI, 1.08-2.48) for having hypertension, 2.4-times higher odds (95%CI, 1.34-4.21) for having diabetes and 1.52 times higher odds (95%CI, 0.97e2.38) for having hypercholesterolemia. Conclusion: Even though elder residents of the continental Mani area enjoyed a lower morbidity rate, elder islanders had a higher level of successful aging; a finding which could be attributed to differences in lifestyle among elders.
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