4B.08

Dimas, G.; Iliadis, F.; Tegos, Thomas; Spiroglou, S.; Kanellos, Ioannis; Karamouzis, I.; Savopoulos, C.; Hatzitolios, Apostolos; Grekas, Dimitrios

doi:10.1097/01.hjh.0000467492.91729.d5

Cited by 6 publications

(2 citation statements)

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“…27 Increased levels of TIMP-1 has been previously suggested as independent risk factors for hypertension, atherosclerosis and albuminuria, primarily in the early stages of diabetic nephropathy in type 2 diabetes to the progression of chronic kidney disease. 28 Besides, TIMP-1 has been suggested as a marker for abnormal regulation of matrix remodelling after a cardiovascular event in patients with type 1 diabetes. 10 Moreover, elevated TIMP-1 plasma levels have been associated with the presence of left ventricular hypertrophy, of heart failure with signs of hypertrophy and myocardial fibrosis and dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy

Papadopoulou-Marketou

Whiss

Eriksson

et al. 2021

Diabetes and Vascular Disease Research

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Background: Tissue inhibitor of metalloproteinase-1 (TIMP-1) has been suggested as a marker for abnormal regulation of tissue remodelling in type 1 diabetes. Metalloproteinase-9 (MMP-9) has been associated with matrix turnover, and Neutrophil gelatinase associated lipocalin (NGAL) is a marker of tubular injury in diabetic nephropathy. The aim was to analyse these biomarkers to unmask early diabetic complications. Methods: Thirty-three type 1 diabetes patients, aged 20–35 years, and disease duration 20 ± 5.3 years were included. Along with clinical examination, neurophysiological measurements, routine biochemistry, plasma concentrations of TIMP-1, MMP-9 and NGAL were determined with immunoenzymatic techniques. Results: TIMP-1 correlated with abnormal unilateral and bilateral vibratory sense foot perception ( r = −0.49 and r = −0.51, respectively), foot neuropathy impairment assessment score (NIA; r = −0.55), neuropathy symptom assessment score ( r = 0.42), microalbuminuria ( r = 0.50) and eGFR ( r = −0.45). MMP-9 correlated with impaired foot NIA ( r = 0.51). Multiple regression analysis showed an association for TIMP-1 ( p = 0.004) with impaired neurophysiological examinations and renal dysfunction along with NGAL ( p = 0.016 and p = 0.015 respectively). Conclusions: This study suggests that plasma levels of TIMP-1, MMP-9 and NGAL may serve as useful biomarkers in unravelling subclinical neuropathy and nephropathy in type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy

Papadopoulou-Marketou

Whiss

Eriksson

et al. 2021

Diabetes and Vascular Disease Research

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Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation

Xue

Cao

et al. 2016

Bioscience Reports

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SynopsisMicro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the increase in urine albumin excretion, urinary β 2 -microglobulin (β 2 -MG), attenuated the decrease in creatinine clearance rate (CCR). The glomerular sclerosis index (1.54 + − 0.33 compared with 0.36 + − 0.07) and tubulointerstitial fibrosis (1.57 + − 0.31 compared with 0.19 + − 0.04) were significantly higher in SHRs compared with Wistar Kyoto rats (WKYs), which were significantly lower by RSV treatment. The increases in mesangium accumulation and the expression of renal collagen type I (Col I), fibronectin (Fn), plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor-β1 (TGF-β1) in SHR were also reduced by RSV treatment. Nuclear factor κB (NF-κB) expression was increased in the cytoplasm and nuclei of the SHR kidneys, which was significantly decreased by RSV treatment. Furthermore, the protein level of IκB-α significantly decreased in the kidneys of the SHR when compared with the WKYs. RSV treatment partially restored the decreased IκB-α level. In SHR kidney, increased expression of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein 1 (MCP-1) were observed. These changes were attenuated by RSV treatment. No changes in blood pressure were detected between SHR group and SHR + RSV group. Taken together, the present study demonstrated that RSV treatment may significantly attenuate renal damage in the SHR model of chronic kidney disease (CKD). The renal protective effect is associated with inhibition of IL-6, ICAM-1 and MCP-1 expression via the regulation of the nuclear translocation of NF-κB, which suggesting that micro-inflammation may be a potential therapeutic target of hypertensive renal damage.Key words: inflammation, intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), nuclear factor κB (NF-κB), resveratrol (RSV), spontaneously hypertensive rat (SHR).

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Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects

Bertolami

Lima-Júnior

Cintra

et al. 2018

Clinical Endocrinology

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4B.08

Cited by 6 publications

References 0 publications

Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy

Plasma levels of tissue inhibitor of metalloproteinase-1 in patients with type 1 diabetes mellitus associate with early diabetic neuropathy and nephropathy

Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation

Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects

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