The effect of smoking on the heart has been a controversial subject. The present studies were undertaken to investigate the effect of cigarette smoking on the coronary flow, myocardial usage of oxygen and myocardial extraction of glucose, pyruvate, lactate, and ketones. Catheterization of the coronary sinus revealed that cigarette smoking in patients without heart disease results in a significant rise in coronary blood flow and heart rate and a significant (Icelilie in coronary vascular resistance and myocardial extraction of oxygen Despite these generally accepted actiolls ons specific tissue, the effect of smoking on the heart has been a controversial subject. The experimental literature on the effect of nicotine on animal and heart-lung preparations is contradictory. In 1912 Meyer,8
Previous studies on the isolated heart have demonstrated that digitalis glycosides can mobilize potussium from the heart muscle. Using catheterization of the coronary sinus of dogs' hearts, it could also be shown that the injection of acetyl strophanthidin results in negative myocardial balances of potassium and in positive balances of sodium. The results described in this report, using Cedilanid in therapeutic dosages, indicate that this glycoside has no effect on the sodium and potassium balance of the human heart. A significant increase in potassium concentration in arterial and coronary sinus blood occurred. The findings suggest that Cedilanid, in therapeutic doses, causes potassium liberation primarily from extracardiac tissues.
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