Effect of a Cardiac Glycoside (Cedilanid) on the Sodium and Potassium Balance of the Human Heart

Gonlubol, F.; Siegel, A.; Bing, Richard J.

doi:10.1161/01.res.4.3.298

Cited by 18 publications

(2 citation statements)

References 8 publications

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“…It is'presumed, then, that this telescoping of the events which sially occur with digitalization enable the detection of changes in plasma concentration arising out of myocardial processes. The failure to demonstrate myocardial ionic exchange after cedilanid (25) can reasonably be ascribed to a less rapid mobilization of potassium.…”

Section: Discussionmentioning

confidence: 95%

Myocardial Response to Acetyl Strophanthidin in Congestive Heart Failure: A Study of Electrolytes and Carbohydrate Substrates*

Regan¹,

Christensen²,

Wada³

et al. 1959

J. Clin. Invest.

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The concept of a defect in the conversion of chemical energy to work as the cause of low output heart failure has been based on the finding of normal myocardial extraction of substrate and oxygen in this clinical state (1, 2). However, the alternative view, that there is failure in transformation of the energy of substrate oxidations to a biologically useful form, cannot be excluded (3). Of particular interest, as regards the former theory, is the problem of evaluating those physical-chemical factors which initiate or contribute to the alteration of myocardial protein in heart failure.A consideration of the role of changes in intracellular ionic content in the regulation of cardiac performance has been stimulated by finding an intimate relation between these parameters in the staircase phenomenon (4). Other isolated muscle work has shown that changes in electrolyte concentration at the superficial level of the cell can affect contractile strength of muscle before the ion penetrates the interior of the muscle (5, 6).Although there is at present no adequate methodology for precise study of these phenomena in the human heart in vivo, it was considered of im-.portance to seek information concerning the myo- (1954)(1955)(1956).:Public Health Trainee of the National Heart Institute (1955)(1956). § Research Fellow, R. C. Mahon Foundation (1956)(1957). Public Health Research Fellow of the National HeartInstitute (1953)(1954)(1955).of drug-induced recovery from cardiac failure. In a prior report (7), data were presented which indicated the facility with which acetyl strophanthidin mobilized electrolytes in the myocardium of the intact dog, its abrupt course of action enabling detection of these changes. METHODSThe design of this study was such as to rely on the assumption that the coronary arteriovenous differences of electrolytes and metabolites could be validly accepted as a measure of their net uptake by, or release from, the myocardium. Although the transcapillary exchange rates of an ion, such as potassium, are blood flow dependent (8), an estimation of the effects of altered blood flow per se upon measured arteriovenous differences appeared in order. In the intact human, two procedures which usually increase coronary blood flow, exercise (9) and hypoxia (10), were chosen to study coronary arteriovenous differences of potassium. Five minutes of exercise produced no significant change in six patients. The mean of the planimetered A-V difference areas for potassium was + 0.01 + 0.08 square inches in the control and + 0.06+ 0.20 in the experimental period. Similar results were obtained with hypoxia, induced by 10 per cent oxygen inhalation for 25 minutes in five patients.The mean control value was + 0.06 + 0.25 square inch and the hypoxia value, + 0.27 ± 0.23. These findings are in agreement with those of Driscol and Berne (11), in which coronary blood in the dog was increased up to 100 per cent by varied procedures without significant change in the potassium arteriovenous differences.The effects of digitalis preparat...

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Section: Discussionmentioning

confidence: 95%

Myocardial Response to Acetyl Strophanthidin in Congestive Heart Failure: A Study of Electrolytes and Carbohydrate Substrates*

Regan¹,

Christensen²,

Wada³

et al. 1959

J. Clin. Invest.

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“…Cardiac glycosides also elevate serum K levels (7,8,9). I t was calculated that the intracel- Mar K (10 mEq K/liter cellular water) released by the hemolyzed erythrocytes would be insufficient to account for all the increased serum K. Approximately 1.6% of the cells were hemolyzed.…”

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confidence: 99%

Effects of Nematocyst Toxin of Physalia physalis (Portuguese Man-of-War) on the Canine Cardiovascular System.

Hastings

Larsen

Lane

1967

Experimental Biology and Medicine

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Recent studies(l,2) have shown that the nematocyst toxin of Physalia physalis (Portuguese Man-of-war) specifically affects the conduction system in both the neurogenic heart of the land cralb (Cardisoma guanhumi) and the myogenic heart of the rat. In earlier experiments the toxin was dissolved and injected immediately because of its extreme lability. Recently a more stable preparation of the toxin has been made, using a phosphate buffer (pH 6.3) that has prolonged activity sufficiently to allow us to observe the response to gradced doses.The present experiments were designed to study the effects of graded doses of P. physalis toxin upon the canine cardiovascular system, with particular emphasis on the EKG, systemic blood pressure, cardiac output, peripheral vascular resistance, and the levels of serum potassium and sodium. Effects of potassium infusion on toxin-induced arrhythmias were also evaluated.Methods. Toxin was prepared as previously described ( 3 ) , with the exception that the nematocysts were homogenized in 5 ml od isotonic Sorensen's phosphate buffer (containg 18.94 g Na2HP04; 18.16 g KH2P04 ; per liter). Following centrifugation (37,000 X g at 4OC for 30 min) the supernatant solution was lyophilized and stored in the cold in evacuated containers. Just prior to infusion, the lyophilized toxin was dissolved in 5% (w/v) dextrose buffered to pH 6.3 to a final concentration of 40 pg/ml. Eight mongrel dogs, 9.6-11.0 kg, were used in this experiment. The dogs were anesthetized with sodium pentobarbital, 28.6 mg/kg, administered intravenously after a 24-hour fasting period. The left carotid artery was ex-

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Influence of Cardiac Glycosides on Electrolyte Exchange and Content in Cardiac Muscle Cells

Nayler¹,

Noack²

1981

Cardiac Glycosides

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Effect of a Cardiac Glycoside (Cedilanid) on the Sodium and Potassium Balance of the Human Heart

Cited by 18 publications

References 8 publications

Myocardial Response to Acetyl Strophanthidin in Congestive Heart Failure: A Study of Electrolytes and Carbohydrate Substrates*

Myocardial Response to Acetyl Strophanthidin in Congestive Heart Failure: A Study of Electrolytes and Carbohydrate Substrates*

Effects of Nematocyst Toxin of Physalia physalis (Portuguese Man-of-War) on the Canine Cardiovascular System.

Influence of Cardiac Glycosides on Electrolyte Exchange and Content in Cardiac Muscle Cells

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