Neonatal sepsis is a clinical syndrome characterized by symptoms of bacteremia and systemic signs and positive blood cultures showed that during the first month of life. Prematurity and postmaturity risk of morbidity and mortality are high on the gestation age for the occurrence of neonatal sepsis. This study aims to determine the relationship between gestational age and the incidence of neonatal sepsis in Ulin Hospital Banjarmasin. The design of this study using cross sectional study with retrospective approach. The way the sampling is the purposive sampling were obtained from medical records of patients, then performed statistical analysis using chi-square test with 95%. The number of samples that fulfilled the criteria inclusion in this study as many as 246 cases. The incidence of neonatal sepsis is more common in infants born at 37-42 weeks gestation as many as 25 cases (59.52%). The data not neonatal sepsis who were born with a gestational age <37 weeks or> 42 weeks gained as many as 20 cases (9.80%) and 37-42 weeks gestation obtained as many as 184 cases (90.20%). Chi-square test showed that there is a relationship between gestational age and the incidence of neonatal sepsis in Ulin Hospital Banjarmasin (p = 0.000) with an odds ratio (OR) 6.256. It is concluded that there is a relationship of gestation age and the incidence of neonatal sepsis (p <0.05) in hospitals Ulin Banjarmasin period June 2014-June 2015 with OR 6.256. Keywords: gestational age, sepsis, neonatal Abstrak: Sepsis neonatorum merupakan suatu sindrom klinis bakteremia yang ditandai dengan gejala dan tanda sistemik serta menunjukkan kultur darah positif yang terjadi pada bulan pertama kehidupan. Prematuritas dan posmaturitas memiliki risiko kesakitan dan kematian yang tinggi pada masa gestasi untuk terjadinya sepsis neonatorum. Penelitian ini bertujuan untuk mengetahui hubungan antara masa gestasi dan kejadian sepsis neonatorum di RSUD Ulin Banjarmasin. Rancangan penelitian ini menggunakan cross sectional study dengan pendekatan retrospektif. Cara pengambilan sampel yaitu dengan purposive sampling yang diperoleh dari data rekam medis pasien, kemudian dilakukan analisis statistik menggunakan uji chi-square dengan kepercayaan 95%. Jumlah sampel yang memenuhi kriteria inklusi dalam penelitian ini sebanyak 246 kasus. Kejadian sepsis neonatorum lebih banyak dijumpai pada bayi yang lahir dengan masa gestasi 37-42 minggu yaitu sebanyak 25 kasus (59,52%). Data neonatus tidak sepsis yang lahir dengan masa gestasi <37 minggu atau >42 minggu didapatkan sebanyak 20 kasus (9,80%) dan masa gestasi 37-42 minggu didapatkan sebanyak 184 kasus (90,20%). Uji chi square menunjukkan bahwa terdapat hubungan antara masa gestasi dan kejadian sepsis neonatorum di RSUD Ulin Banjarmasin (p=0,000) dengan odds ratio (OR) 6,256. Kesimpulan penelitian ini adalah terdapat hubungan masa gestasi dan kejadian sepsis neonatorum (p<0,05) di RSUD Ulin Banjarmasin periode Juni 2014-Juni 2015 dengan OR 6,256. Kata-kata kunci: masa gestasi, sepsis, neonatus
<p>Imunoterapi alergen (allergen immunotherapy/AIT) adalah pilihan terapi yang terbukti efektif untuk rinitis alergi baik melalui rute sublingual (SLIT) maupun subkutan (SCIT). AIT dalam jangka panjang dapat menurunkan kadar IgE secara signifikan pada pasien rinitis alergi berat; tetapi efektivitas terapi dapat berkurang setelah AIT dihentikan. Terapi vitamin D dipercaya dapat meningkatkan efektivitas AIT. Studi bertujuan menilai efektivitas suplementasi vitamin D3 pada pasien rinitis alergi yang menjalani imunoterapi ditinjau dari kadar IgE. Penelitian menggunakan metode literature review terkait ilustrasi kasus. Pencarian artikel melalui Pubmed dengan kata kunci terkait dan dipilih berdasarkan kriteria inklusi dan eksklusi. Dari hasil penyaringan didapatkan dua studi yang sesuai kriteria, yaitu studi oleh Yu, et al, dan oleh Maghraby, et al. Pada kedua studi terdapat penurunan signifikan kadar IgE pada kelompok yang menjalani AIT dengan suplementasi vitamin D dibandingkan kelompok tanpa suplementasi vitamin D. Vitamin D terbukti meningkatkan efektivitas imunoterapi pada pasien rinitis alergi.</p><p> </p><p>Allergen immunotherapy (AIT) is a therapeutic option that has been shown to be effective for allergic rhinitis by the sublingual (SLIT) or subcutaneous (SCIT) routes. AIT in the long term can significantly lower IgE levels in severe allergic rhinitis patients; however, its effectiveness may decrease after AIT is discontinued. Vitamin D therapy is believed to be able to increase the effectiveness of AIT. This study aims to assess the effectiveness of vitamin D3 supplementation in allergic rhinitis patients undergoing immunotherapy in terms of IgE levels. The study used a literature review method related to case illustrations. Article search was through Pubmed with related keywords and selected based on inclusion and exclusion criteria. Two studies met the criteria, the study by Yu, et al, and by Maghraby, et al. In both studies, there was a significant reduction in IgE levels in the AIT group with vitamin D supplementation compared to the group without vitamin D supplementation. Vitamin D has been shown to increase the effectiveness of immunotherapy in patients with allergic rhinitis.</p>
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