<p>Imunoterapi alergen (allergen immunotherapy/AIT) adalah pilihan terapi yang terbukti efektif untuk rinitis alergi baik melalui rute sublingual (SLIT) maupun subkutan (SCIT). AIT dalam jangka panjang dapat menurunkan kadar IgE secara signifikan pada pasien rinitis alergi berat; tetapi efektivitas terapi dapat berkurang setelah AIT dihentikan. Terapi vitamin D dipercaya dapat meningkatkan efektivitas AIT. Studi bertujuan menilai efektivitas suplementasi vitamin D3 pada pasien rinitis alergi yang menjalani imunoterapi ditinjau dari kadar IgE. Penelitian menggunakan metode literature review terkait ilustrasi kasus. Pencarian artikel melalui Pubmed dengan kata kunci terkait dan dipilih berdasarkan kriteria inklusi dan eksklusi. Dari hasil penyaringan didapatkan dua studi yang sesuai kriteria, yaitu studi oleh Yu, et al, dan oleh Maghraby, et al. Pada kedua studi terdapat penurunan signifikan kadar IgE pada kelompok yang menjalani AIT dengan suplementasi vitamin D dibandingkan kelompok tanpa suplementasi vitamin D. Vitamin D terbukti meningkatkan efektivitas imunoterapi pada pasien rinitis alergi.</p><p> </p><p>Allergen immunotherapy (AIT) is a therapeutic option that has been shown to be effective for allergic rhinitis by the sublingual (SLIT) or subcutaneous (SCIT) routes. AIT in the long term can significantly lower IgE levels in severe allergic rhinitis patients; however, its effectiveness may decrease after AIT is discontinued. Vitamin D therapy is believed to be able to increase the effectiveness of AIT. This study aims to assess the effectiveness of vitamin D3 supplementation in allergic rhinitis patients undergoing immunotherapy in terms of IgE levels. The study used a literature review method related to case illustrations. Article search was through Pubmed with related keywords and selected based on inclusion and exclusion criteria. Two studies met the criteria, the study by Yu, et al, and by Maghraby, et al. In both studies, there was a significant reduction in IgE levels in the AIT group with vitamin D supplementation compared to the group without vitamin D supplementation. Vitamin D has been shown to increase the effectiveness of immunotherapy in patients with allergic rhinitis.</p>
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