Doripenem showed excellent activity against Gram-negative isolates; generally it was more active than imipenem and at least as good as meropenem. Against Pseudomonas species, doripenem was more active than both imipenem and meropenem, with doripenem susceptibility observed for some imipenem- and/or meropenem-resistant isolates.
The integration of facility management and building information modelling (BIM) is an innovative and critical undertaking process to support facility maintenance and management. Even though recent research has proposed various methods and performed an increasing number of case studies, there are still issues of communication processes to be addressed. This paper presents a theoretical framework for digital systems integration of virtual models and smart technologies. Based on the comprehensive analysis of existing technologies for indoor localization, a new workflow is defined and designed, and it is utilized in a practical case study to test the model performance. In the new workflow, a facility management supporting platform is proposed and characterized, featuring indoor positioning systems to allow end users to send geo-referenced reports to central virtual models. In addition, system requirements, information technology (IT) architecture and application procedures are presented. Results show that the integration of end users in the maintenance processes through smart and easy tools can overcome the existing limits of barcode systems and building management systems for failure localization. The proposed framework offers several advantages. First, it allows the identification of every element of an asset including wide physical building elements (walls, floors, etc.) without requiring a prior mapping. Second, the entire cycle of maintenance activities is managed through a unique integrated system including the territorial dimension. Third, data are collected in a standard structure for future uses. Furthermore, the integration of the process in a centralized BIM-GIS (geographical information system) information management system admit a scalable representation of the information supporting facility management processes in terms of assets and supply chain management and monitoring from a spatial perspective.
NF bacteraemia mainly affects patients with malignant haematological disease, with and without transplantation, and patients in the ICU. The most common known source is a central venous catheter, though many sources are unknown. Mortality is relatively low, and depends on the severity of the underlying disease.
The rate of P aeruginosa bacteremia is falling slightly at our hospital. The emergence of the human immunodeficiency virus epidemic has had a considerable impact on both epidemiology and mortality. The presence of severe underlying disease, surgery, pneumonia, and, especially, severe sepsis are associated with a poor outcome. With the exclusion of patients with intravenous catheter-associated P aeruginosa bacteremia, the administration of an appropriate antimicrobial therapy is essential to a good outcome. Treatment with 1 active antibiotic seems to be sufficient.
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