This cross-sectional study, carried out on a cohort of 568 HIV-infected patients followed at the Bertoua Day Hospital, aimed at assessing interventions used in the biomedical management of lipodystrophy and metabolic syndrome related to Antiretroviral therapy through the determination of their prevalence within this hospital. Patients had a minimum age of 18years old, a minimum duration of 2years antiretroviral therapy and all had given their informed consent to participate in the study. The mean duration of treatment for HIV patients with lipodystrophy cases was 68±9.2 months ranged from 24 to 136months and that for patients with metabolic syndrome cases was 46±8.5 months ranged from 24 to 151months (P value = 0.005). Lipodystrophy was observed with all the therapeutic protocols prescribed to HIVinfected patients in our study site. Lipodystrophy cases seen among HIV-infected patients using the d4T in their therapeutic protocol accounted for 41.11%, while those seen among HIV-infected patients using the AZT in their therapeutic protocol accounted for 51.57% (P <0.0001). Among HIV-infected patients using the NVP in their therapeutic protocol, we found 40.41% of lipodystrophy cases versus 28.23% of lipodystrophy cases among HIV-infected patients using the EFV in their therapeutic protocol (P value=0.01). Lipodystrophy cases related to the use of protease inhibitors in the therapeutic protocol accounted for 31.36%. The prevalence of metabolic syndrome cases was greatest among HIV-infected patients using protease inhibitors boosted by the ritonavir in their therapeutic protocol with 72.6% of cases (P value = 0.0003). The prevalence of metabolic syndrome cases determined in this study using the definition of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) was 21.83% and that of lipodystrophy cases was 50.52% with 27.64% for lipoatrophy cases, 20.95% for lipohypertrophy cases and 1.93% for mixed syndrome cases (P value = 0.01). We also found 16.9% for lipodystrophy cases strongly associated with the metabolic syndrome among our HIV infected patients under HAART, with an Odds Ratio of 4.54 which was statistically significant with a confidence interval (CI) between 3.45 and 6.87 to 95% (P value = 0.03). In other words, these HIV infected patients were 4.54 times more likely to have a metabolic syndrome in the presence of lipodystrophy than in its absence.
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