The physiologic effect of the transfusion of preserved red cells with low 2,3-diphosphoglycerate (2,3-DPG) levels and high affinity for oxygen has not been established. No significant effect on systemic oxygen consumption or cardiac index was observed following the infusion of 3 to 5 units of T Cardiac index T Pre r + i Tx Hours Fig. 1. The mean (& SD) oxygen consumption (ml/min/ma) and the cardiac index (l/min/m2) of 7 patients prior to and following therapeutic transfusions. washed acid-citrate-dextrose (ACD, National Institutes of Health, Formula A)-collected red cells that had been stored a t 4°C for a t least 2 weeks into each of 8 anemic patients who required therapeutic transfusions a t the rate of approximately 20 ml/min (fig. 1) [l].
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