[reaction: see text] The structures of novel gaudichaudiic acids F-I (1-4), isolated from the bark of Indonesian Garcinia gaudichaudii, have been elucidated by detailed spectral analysis. Gaudichaudiic acid I (4) is probably derived from 1 as a result of allylic oxidation at C-24 and C-21, followed by aromatization.
Rosacea is a chronic inflammatory skin disease characterized by central facial erythema with or without ocular involvement. It is often difficult to distinguish rosacea from other malar rashes, one of which is acute cutaneous lupus erythematosus (CLE), particularly when there is an increase in antinuclear antibody (ANA) level. We report the case of a 16-year old woman with facial erythematous plaque accompanied by papules and pustules, reddened eyes, and swollen eyelids since the last one year. Dermoscopic examination revealed telangiectasia, and skin scraping examination with 20% potassium hydroxide identified the presence of<i> Demodex folliculorum</i>. Further ocular examination also revealed blepharitis, dysfunction of Meibomian gland, cicatrix, and corneal neovascularization. The ANA titer was positive (1:320), while the anti-dsDNA was negative. The patient was treated according to standard treatment for rosacea. The patient showed a satisfactory response following 2 weeks of therapy. Signs of recurring red patches with papules, pustules, telangiectasia, and identification of <i>D. folliculorum</i> on skin scraping examination led to the diagnosis of papulopustular rosacea. A positive ANA test may also be present in other diseases, e.g. acute CLE. Therefore, the diagnosis of rosacea remains a challenge. Thorough observation and examination must be done in order to yield an accurate diagnosis of rosacea.
Psoriasis merupakan peradangan kulit kronik dengan dasar genetik. Untuk mencapai remisi dan kualitas hidup yang baik, pilihan terapi disesuaikan dengan kebutuhan perorangan pasien. Tipe dan derajat keparahan psoriasis perlu ditentukan guna memilih tata laksana yang sesuai karena memengaruhi keberhasilan terapi, masa remisi, serta tingkat morbiditas. Penelitian ini bertujuan menilai kesesuaian tata laksana psoriasis berdasarkan derajat keparahan dengan menggunakan Panduan Praktik Klinis (PPK) RSUPN dr. Cipto Mangunkusumo (RSCM) dan Persatuan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI). Studi retrospektif ini mengambil subjek seluruh pasien baru psoriasis di Divisi Alergi Imunologi, Departemen Ilmu Kesehatan Kulit dan Kelamin RSCM periode Oktober 2017 – Oktober 2018. Keparahan psoriasis dinilai dengan skor body surface area (BSA) dan psoriasis area severity index (PASI). Sebanyak 32 di antara 35 pasien (91,4%), skor BSA dan/atau PASI terdokumentasi pada rekam medis, dan 30 di antara 32 pasien (93,8%), mendapatkan pilihan terapi sesuai dengan tipe psoriasis atau skor BSA dan/atau PASI. Kepatuhan pasien sangat penting sehingga pemilihan tata laksana psoriasis perlu mempertimbangkan kenyamanan pasien terkait efek samping pengobatan, kemudahan pasien untuk mengakses fasilitas, dan aspek ekonomi. Kesesuaian terapi tidak mencapai 100% karena kontraindikasi pemberian terapi standar, penolakan pasien, dan ketidaktersediaan obat misalnya metotreksat. Sebanyak 93,8% pasien psoriasis di RSCM telah ditata laksana sesuai dengan PPK RSCM dan PERDOSKI.Kata Kunci: BSA, PASI, psoriasis, tata laksana
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.