This work aimed to synthesize new Ibuprofen amino acid derivatives as safe non-steroidal anti-inflammatory drugs (NSAIDs). The structures of the synthesized compounds have been determined using various spectral data. For tested compounds, molecular docking was performed into the cyclooxygnase-2 (COX-2) active site. The lowest root-mean-square deviation of atomic positions (RMSD) pose has been chosen for the binding affinity discussion. Docking protocol revealed that the binding interaction increased by the presence of hydrazide fragment in the tested compounds. Passed compounds through docking profile were examined for their anti -inflammatory and analgesic activities. Using a carrageenan-induced mouse model of hind paw edoema, we investigated the potential anti-inflammatory efficacy of the synthetic compounds in comparison to their parent molecule, ibuprofen. In addition to assessing the antinociceptive and ulcerogenic properties of the synthesized compounds Keywords NSAIDs; Peptide candidates; Anti-inflammatory and Analgesic agents; docking
New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives were synthesized, characterized and evaluated as antimicrobial agents. Phathalic anhydride was reacted with aminoacetoactate to afford phthalimide derivative which reacted with hydrazine hydrate to give New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivative 1. Compound 1 is used as precursor to synthesize various derivatives depending on types of reactants. Spectroscopic and analytical measurements are used to confirm structures of new products. Antimicrobial evaluation of new derivatives were done.
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