Synthesis, Reactions, and Antimicrobial Evaluation of 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives

Abstract

New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives were synthesized, characterized and evaluated as antimicrobial agents. Phathalic anhydride was reacted with aminoacetoactate to afford phthalimide derivative which reacted with hydrazine hydrate to give New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivative 1. Compound 1 is used as precursor to synthesize various derivatives depending on types of reactants. Spectroscopic and analytical measurements are used to confirm structures of new products. Antimicrobial evaluation of new derivatives were done.