Background: Depression occurs in one-third of stroke patients, in what is known as poststroke depression. The lesion sites in stroke have been associated with the degree of depression. However, studies have provided different perspectives, and this necessitates further clarification. This study investigates the relationship between the lesion sites and the severity of depression in ischemic stroke patients. Methods: This cross-sectional study was conducted between January and April 2020. All samples were obtained from admitted patients with ischemic stroke who agreed to participate in the study. Data were collected using Beck's Depression Inventory-II (BDI-II), which was used to determine the severity of depression, and the lesion sites were based on radiological imaging interpretation. Results: The study showed a significant association between the lesion site and the degree of depression (OR = 5,368, p-value = 0,013). Lesions in the frontal lobe demonstrated stronger associations with the severity of depression. Conclusion: The location of the lesion, especially in the frontal lobe, was associated with more severe post-stroke depression.
Manifestasi neurologis pada COVID-19 luas dan bervariasi. Kami melaporkan kasus ensefalopati pada COVID-19 dengan manifestasi gangguan perilaku dan kognitif, kejang, dan penurunan kesadaran, pada seorang laki-laki usia 47 tahun yang terdiagnosis positif COVID-19 dua minggu sebelumnya. Pada pemeriksaan fisik, pasien tampak gelisah dan disorientasi. Pada pemeriksaan neurologis tidak ditemukan defisit fokal. Hasil pemeriksaan laboratorium dan CT scan kepala nonkontras ditemukan dalam batas normal, dan hasil polymerase chain reaction (PCR) swab nasofaring positif. Hasil lumbal pungsi signifikan untuk peningkatan protein (0,54g/L) dengan jumlah sel dan gula normal, dan hasil PCR pada CSS tidak menemukan adanya SARS-CoV-2. Pasien mendapatkan terapi dengan remdesivir, dexamethasone, heparin, antibiotik, dan fenitoin, dan dirawat selama 8 hari dengan perbaikan. Dilakukan evaluasi fungsi luhur tiga minggu pasca awitan gejala, dan ditemukan penurunan fungsi atensi dan memori jangka pendek ringan. Manifestasi neurologis pada COVID-19 berupa penurunan kesadaran, kejang, gangguan perilaku, serta gangguan fungsi kognitif dapat muncul pada pasien tanpa faktor risiko jelas, dan timbul pada periode setelah fase akut dari infeksi SARS-CoV-2, yang mungkin disebabkan oleh respons imun yang belum sepenuhnya berhenti akibat masih terdapatnya sejumlah kecil virus di dalam tubuh.
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