Although the study of RNA therapeutics started decades ago, for many years, this field of research was overshadowed by the growing interest in DNA-based therapies. Nowadays, the role of several types of RNA in cell regulation processes and the development of various diseases have been elucidated, and research in RNA therapeutics is back with force. This short literature review aims to present general aspects of many of the molecules currently used in RNA therapeutics, including in vitro transcribed mRNA, antisense oligonucleotides, aptamers, small interfering RNAs, and microRNAs. In addition, we describe the state of the art of technologies applied for synthetic RNA manufacture and delivery. Likewise, we detail the RNA-based therapies approved by the FDA so far, as well as the ongoing clinical investigations. As a final point, we highlight the current and potential advantages of working on RNA-based therapeutics and how these could lead us to a new era of accessible and personalized healthcare.

Here, we developed a nano-engineered biomaterial optimized for skeletal muscle proliferation and differentiation. Nanoclay disks were used to control the release of insulin-like growth factor (IGF-1), a key myogenic and immunogenic regulator.

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Pesticides have become necessary control agents to guarantee food sovereignty and strengthen development in Ecuador. Nevertheless, the current management practices of pesticides in Ecuador restrain the progress of agriculture in this region. There is evidence of a knowledge gap regarding the correct handling of pesticides and the possible health impacts they generate, especially in small producers and surrounding communities. Furthermore, a lack of updated information on pesticide registration difficult their control and distribution. Given this, there is a need to implement new public policies that promote relations between science and technology, not only with the industry but also with local producers, to promote the growth of agriculture, minimizing risks to health and the environment in the sectors involved. The purpose of this review is to exhibit the most updated panorama regarding the management of pesticides in Ecuador.