The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced cnbp expression through an NF-κB-dependent manner and a positive autoregulatory mechanism, which enables prolonged il-6 gene expression. This event depends strictly on LPS-induced CNBP nuclear translocation through phosphorylation-mediated dimerization. Consequently, cnbp-depleted zebrafish are highly susceptible to Shigella flexneri infection in vivo. Collectively, these observations identify CNBP as a key transcriptional regulator required for activating and maintaining the immune response.
BACKGROUND
Recently, the high prevalence of problematic digital media use among youth has become a public concern. Therefore, this study investigated digital citizenship's moderating effects on a supportive school environment, parental pressure to achieve, academic stress, problematic digital media use, and happiness in school‐aged children.
METHODS
This cross‐sectional study involved secondary data analysis of national data from the 11th Panel Study on Korean Children 2018 on 1342 families of fourth‐grade students. Structural equation modeling assessed the relations among variables.
RESULTS
A multigroup analysis verified that digital citizenship significantly moderated the paths from supportive school environment to problematic digital media use, supportive school environment to happiness, and problematic digital media use to happiness. Specifically, problematic digital media use had a significant positive effect on happiness in the low‐digital citizenship group and a significant negative effect in the high‐digital‐citizenship group.
CONCLUSIONS
These findings indicate that digital citizenship as a competency should be fostered to prevent problematic digital media use.
Purpose: Understanding the influence of perfectionism among senior nursing students is imperative for addressing strategies to reduce career distress and enhance job search behavior. The purpose of this study was to identify perfectionism types among senior nursing students in South Korea. Differences in career distress and enhanced job search behavior for each perfectionism type were compared.Methods: A cross-sectional, descriptive design was employed. A total of 211 nursing students completed surveys for Perfectionism, Job Search Behavior, and Career Distress. Cluster analysis and post-hoc tests were conducted.Results: A total of 80.1% were classified into the perfectionism group, including adaptive (49.8%) and maladaptive (30.3%). Maladaptive groups showed the highest discrepancy between standards and their perceived achievements as well as career distress. Job search behavior was the highest in the adaptive perfectionism group but the lowest in the non-perfectionism group.Conclusion: Nursing educators should consider career coaching customized by each perfectionism type to improve job search behavior among nursing students.
This study was conducted to understand the association between character strength and mental health problems among children in early adolescence from low-income families in South Korea. This study used a cross-sectional and descriptive study design with 214 fifth- and sixth-grade elementary school children from low-income families enrolled in 20 community centers and receiving government financial assistance. A bivariate probit model was used to examine the association between character strength and mental health problems in the children. We found that character strength lowers the likelihood of developing hyperactivity–inattention and emotional symptoms among children from low-income families. Additionally, adverse life events were associated with increased mental health problems, whereas adverse life events were not significantly correlated with character strength in the current study. Specific interventions should be developed to cultivate character strength among children in early adolescence from low-income families who are at a high risk of mental health problems under cumulative adverse life events.
Purpose: This study aims to analyze the mediation role that impulsivity plays between social stigma and SNS cyberbullying when moderated by parental attachment.Methods: This study is a secondary analysis using the raw data from panel survey of adolescents who have dropped out of school provided by the Korea Youth Policy Research Institute, and the total number of samples is 576 cases. SPSS V.25 and PROCESS macro for SPSS V.3.5.2 were used for data analysis.Results: In the relationship between social stigma and SNS cyberbullying behavior, impulsivity showed a statistically significant positive completely mediating effect. Parental attachment was found to control impulsivity as a parameter and SNS cyberbullying as a dependent variable, and thus the mediated moderating effect was verified.Conclusion: Based on the results of this study, it was confirmed that parental attachment plays a role as a regulatory mechanism to lower impulsivity. More specifically, in controlling impulsivity caused by the social stigma of school-dropped adolescents, support based on parental attachment of parents is absolutely necessary.
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