Aim: The study is aimed at investigating the antinutritive effects of aqueous root extract of Moringa oleifera on haematological indices following sub-chronic consumption of alcohol in Wistar rats. Methods and Materials: Thirty (30) experimental rats weighing 100-120 g were randomly divided into 6 groups of 5 rats each. Group 1, the normal control group was given just rat feed and water, group 2, negative control was administered alcohol only (1.5 ml/kg body weight), rats in group 3, 4 and 5 received combined administration of alcohol 1.5 ml/kg body weight and 200, 400 and 600 mg/kg body weight of aqueous root extract of Moringa oleifera respectively, group 6 rats were administered 250 mg/body weight of extract only. At the end of fourteen days (14) the experimental rats were then sacrificed, and blood was collected for haematological analysis. Results: The result obtained shows a dose-dependent response in almost all the parameters, white blood cell (WBC) count increases significantly(P<0.05) with 600 mg/kg while dose 200 mg/kg and 400 mg/g shows no significant change. Red blood cells (RBC) decreases non-significantly (P<0.05) with increased amount of aqueous Moringa root extract. Likewise, there was also a dose-dependent decrease in the haematological count and more noticeable with 200 mg/kg dose. It was also observed that mean corpuscular haemoglobin concentration (MCHC) and mean corpuscular volume (MCV) increases in all the treatment groups with significant observed in 400 mg/kg and 600 mg/kg. The increase in alcohol can bring about suppression of the blood cells production, enhance if there is reduction in the red blood cells, it, therefore, implies that the will be reduction in the oxygen-carrying capacity of the red blood cells, that would be carried to the tissues as well as the level of carbon dioxide returned to the lungs. Also, the PCV is involved in the transport of oxygen and absorption of the nutrient. Therefore, increase in PCV, shows a better transportation and thus results in an increase in both primary and secondary polycythemias. Conclusion: This research work shows that the plant extract contains some bioactive component or phytochemical constituents that are capable of ameliorating the toxicity effect of alcohol on animal models.
The study was carried out to investigate the anti-diabetic effects of two medicinal plants Cataranthus roseus (C.R) and Nauclea latifolium (N.L) on some biochemical indices of streptozotocin induced diabetic albino wistar rats. Methods: Ethanolic leaf extracts of C.R. and N.L. were given at daily doses of 500 mg/kg body weight in two divided doses each for 14 days. Thirty albino wistar rats were divided into five (5) groups, consisting of 6 rats each viz: Group 1(normal control), Group 2 (diabetic control), Group 3 (insulin treated), Group 4 (received N.L) and Group 5 (received C.R.). Results: The results of the phytochemical screening contain flavonoids, polyphenols, and alkaloids were found to be present in appreciable amount in N.L while saponins and tannins were found in traceable concentration. Fasting blood glucose levels showed significant decrease (P<0.05) in all the test groups compared to diabetic control and closely related to the insulin treated groups. A significant increase (P<0.05) was observed in (TG) and (TC) concentration of all treated groups compared to the diabetic control group. The concentration of HDL was significantly increased while there was also a significant decreased (P<0.05) in VLDL and LDL in the diabetic control group and insulin group when compared to the normal control group, except for C.R treated group that shows a significant decrease compared with the diabetic control group. Enzymes activities were increased in insulin and diabetic groups. A significant reduction (P<0.05) was observed with the treated group of C.R. and N.L compared to the normal control group. Also, observed was a decrease in albumin level in groups treated with the extracts. Marked reduction in total protein level was observed in groups treated with extracts and insulin, compared to the normal control group. Serum concentrations of Na+, K+, Cl- in diabetic control groups showed a significant increase (P<0.05) compared to the normal control group. K+ concentration was observed to be significantly decreased (P<0.05) in all groups treated with extract and insulin compared to the normal control group. Conclusions: The results demonstrated that C. roseus and N. latifolium have anti-diabetic and antihepatotoxic properties and could be potential herbal remedy in treating and managing diabetic conditions.
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