We found that CD14(++)CD16(+) monocytes were independently associated with CV events in non-dialysis CKD patients. Our results support the notion that CD16(+) monocytes rather than CD16(-) monocytes are involved in human atherosclerosis.

A decreased expression of the fibroblast growth factor (FGF)-23 coreceptor Klotho was postulated as an early alteration in chronic kidney disease mineral and bone disorder, resulting in a compensatory increase in plasma FGF-23 levels. Klotho exists in both membrane-bound and secreted (sKlotho) forms, the latter of which may exert vasculoprotective effects. Here we analyzed plasma sKlotho levels in a large cohort of 312 patients with stage 2-4 chronic kidney disease, and assessed plasma levels of FGF-23, sKlotho, parathyroid hormone, and urinary fractional phosphate excretion. Patients were prospectively followed for an average of 2.2 years for the occurrence of death or initiation of renal replacement therapy. The levels of sKlotho were significantly associated with age, but not with the glomerular filtration rate or other parameters of calcium-phosphate metabolism. Moreover, while patients with high FGF-23 levels faced worst outcome even after adjustment for confounders, we found no prognostic impact of sKlotho. Thus, plasma levels of sKlotho were not related to kidney function and did not predict adverse outcome in patients with chronic kidney disease. Future studies are needed to understand how tissue expression, urinary excretion, and plasma levels of Klotho diverge in progressive chronic kidney disease.

In patients with chronic kidney disease, renal RIs do not selectively indicate organ damage, but also mirror systemic vascular disease. The authors introduced DI-RISK as a potential US marker that may more specifically reflect kidney damage.

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Double-physician couples being parents have been shown to face greater difficulties in combining their private and professional lives when compared to other couples. In the present study, we aimed to analyze how double-physician couples manage to arrange their roles in their private and professional lives and how compatible their individual idea of being a mother or a father is with their career as a physician. Fifteen couples being parents and consisting of either two surgeons or a surgeon and a nonsurgeon were asked to participate in a survey to determine the average maternity or paternity leave, the reduction of hours worked per week after the birth of a child, and the need for professional childcare and additional support in childcare from relatives or babysitters per week. Furthermore, the couples were asked to mark on a six-item Likert scale how compatible their professional life is with their idea of being parents. The average maternity or paternity leave was 13 ± 2 months per child and the mean reduction of hours worked per week was 30 ± 12%. The couples made use of professional childcare for 41 ± 6 h/week on average and needed additional support in childcare from relatives or babysitters for 5 ± 3 h/week. On the Likert scale from “completely incompatible (0)” to “perfectly compatible (5)”, the mean compatibility of professional and private lives was rated 2.5 ± 1.1. Becoming parents significantly influences the professional and private lives of double-physician couples. The relatively low compatibility of double-physician couples’ private and professional lives might lead to relevant work-home conflicts. Such conflicts have been proven to be associated with surgeons not recommending surgery as a career. Therefore, efforts should be made to improve the compatibility of parenthood and a medical career.

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