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The study aimed to evaluate the effect of different output powers of Er:YAG laser on microtensile bonding strength of indirect composite to resin cements.36 indirect composite blocks (GC Gradia DA2, Japan) size 15 × 10 × 10 mm(3) were constructed, and divided into 12 groups, as follows:G1: control group (no treatment); Groups G2 to G6: treated with Er:YAG laser (2,940 nm) in noncontact mode, frequency 20 Hz, pulse duration 470 µs, with output power ranging from 2W to 6W; Groups G7 sandblasting, Groups 8 to G12: as Groups G2 to G 6 with preparatory sandblasting. One specimen from each group was analyzed by SEM; each specimen was fixed to a specialized metal jig using cyanoacrylate (Mitreapel, Beta Kimya San. Ve TIC, Iran) and debonded under tension with a universal testing machine (Zwick, Germany) at a crosshead speed of 0.5 mm min(-1). Sandblasting and laser can improve bond strength above an energy level of 150 mJ. SEM evaluation of laser-treated specimens showed irregularities and deep undercuts. T test analysis showed no significant difference between sandblasted and non-sandblasted group, with laser output power of 0, 100, or 150 mJ (P = 0.666, P = 0.875, and P =  .069); in the specimens irradiated with energy output of 200, 250, or 300 mJ, sandblasted specimens showed higher bond strength than non-sandblasted ones. The results demonstrate that, in composite resin irradiated with laser at energy output of 200-300 mJ, sandblasting might be a suitable procedure to enhance bond strength of resin cement.