Background:
We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D)
and to investigate the correlation between vitamin D and metabolic imbalance.
Material and Methods:
For our study, we selected thirty-one patients with T1D without complications
and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World
Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin
and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated
haemoglobin (HbA1c) and ionogram were also analysed.
Results:
Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls
(P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results
show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration
averages.
Conclusion:
Our results indicate that the deficiency of VD is associated with an increased risk of
T1DM in Algerian population.
Background:
Diabetic nephropathy is a common worldwide multifactorial disease where
involvement of genetic factors is well etablished. The aim of this study was to investigate the HLA
genes implication in the development of type 1 diabetic nephropathy.
Methods:
We performed a case- control study where one hundred and fifty subjects were examined.
Patients were divided in two groups; with and without type 1 diabetic nephropathy. HLA typing was
performed using Polymerase Chain Reaction- Sequence Specific Oligonucleotide (PCR- SSO) method.
HLA association to clinical phenotype and HLA haplotype analysis was also investigated.
Results:
HLA B*51 is increased in patients without type 1 diabetic nephropathy (7.14% vs. 0 %, P <0.05,
OR= 0), however no other studied alleles seem to have any effect (all P>0.05). Haplotype analysis also
does not reveal any significant association, however, A*02-B*18-DRB1*03-DQA1*05- DQB1*03 haplotype
shows a tendency to be associated with the development of diabetic nephropathy (P = 0.05).
Conclusion:
These results suggest a protective effect of HLA B*51 allele from type 1 diabetic nephropathy.
However, further studies are required in order to clarify its potential implication as a protective
marker.
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