The subcutaneous injection of epinephrine in doses of 1 mg. per kilo brings about a polycythemia, an increase in reticulocytes, and an increase in young forms of polymorphonuclear leucocytes. The polycythemia is no doubt in part a concentration phenomenon, but the presence of these young cells in increasing numbers is believed to be evidence that there is at the same time a discharge of cells from the blood-forming organs, due to the effect of the drug upon them. A similar effect is obtained by continued stimulation of the peripheral ends of the cut sciatic nerves in the curarized animal.
499foetal life. Sixteen, 17, and 18-day embryos were similarly injected. Gonads of both sexes were preserved for sectioning at various stages of both injected and non-injected animals. All material was fixed in Bouin's solution.Prenatal injection in no way hastened the differentiation in the gonad. It is thus evident that the gonad of the rat foetus is i n c a p able of response to the pituitary hormone. No evidence of sexual maturity was observed in either sex until the tenth day of postnatal life, when the effect was most pronounced in the male. This effect evinced itself in an apparent increase in tubule length as well as by a considerable thickening of the tubular wall. There is an undoubted increase in the size of the interstitial cells, and the tissue presents a dense and closely-packed appearance. We attribute this close-packed appearance to the increase in length and diameter of the tubules. No reconstructions have as yet been made to render this point a certainty.In the ovary the earliest advance in maturity of the injected animals over the controls appeared at approximately the fifteenth day. No corpora lutea were present but the follicles are larger in diameter and more nearly approaching maturity than in the normal animal if judged by the amount of follicular fluid present. At the twentieth day this precocious development is more marked. In no case were corpora lutea observed nor could eggs be discerned within the lumen of the sectioned tube.On the basis of the above results, the physiological effect of the pituitary hormone upon the gonad first shows itself in both. sexes between the tenth and fifteenth days of postnatal life.
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