Background Recurrent pregnancy loss (RPL) presents one of the main problems in the field of reproductive medicine, due to the unknown etiology in 50% of cases, as well as limited evidence-based diagnostic and therapeutic modalities. Recent studies indicate that systemic and placental oxidative stress (OS) represents an essential factor in the etiopathogenesis of RPL. This article is a comprehensive narrative synthesis of previously published studies concerning the role of oxidative stress in the etiology of recurrent pregnancy loss. Methods We conducted literature search of published studies in the English language focusing on oxidative stress and its association with recurrent pregnancy loss (RPL) utilizing the Medline and Cochrane databases from 2000 through January 2021. The keywords used were “recurrent pregnancy loss” “oxidative stress and recurrent pregnancy loss” and “oxidative stress biomarkers and recurrent pregnancy loss”. Results The search yielded 1116 publications, of which 92 were included in the final analysis. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) at basal levels have various physiological functions whereas deviation from redox window is associated with different pathologies including early pregnancy loss. The currently available studies support the concept that increased oxidative stress (OS) and deficient antioxidant protection is implicated in the etiology of recurrent pregnancy loss (RPL) but underlying mechanisms through which OS affects pregnancy outcome remains largely indefinable. Conclusions Future research in this field can provide new insights regarding the OS-mediated damage in recurrent pregnancy loss as well as potential applications of antioxidant therapy in this group of patients.

Above 70% of sexually active women and men will be infected with human papilloma irus at some point in their lives, and several may yet be infected in more than one circumstance. Around 80% of sexually active women acquire HPV infection, while for the most part, they are asymptomatic with the immune system-mediated clearance of contagion within 6–12 months. High-risk papillomavirus is accountable for causing cancer associated with the cervix, vulva, vagina, anus, penis, and oropharynx. This survey aims to investigate the level of knowledge among residents in the Republic of Kosova regarding human papillomavirus (HPV) infections and HPV-associated diseases and to discover the relationship between these factors. Material and methods: A cross-sectional survey was performed by investigating the knowledge concerning HPV infection in the population aged 18 to 35+ years. The study was conducted in the interval from June 2021 - August 2021. The sample included 500 participants. The questionnaire was anonymous, and participants were free to end the participation at any time, without finishing the questionnaire. Results: More than half of the respondents knew about HPV - 70.0%, and 29.6% did not know. Respondents with secondary and higher education showed 18 times more knowledge for HPV (OR = 18.1311 95% CI: 8.7465-37.5852) than respondents with primary education. To the question Can HPV cause cancer of the cervix, 37.2% (n=186) of the respondents gave a correct answer. The results presented that most participants knew what HPV was (70%), but they also revealed that most participants had low or moderate knowledge about HPV, which was a comparable result with earlier studies. A small number of participants in this survey knew that HPV could heal by itself (12.8%), which was similar to results presented in other surveys. Conclusions: It is important to improve the inadequate knowledge about HPV among the population in the Republic of Kosova. In order to do that, it could be significant to assess which factors affect the knowledge so that young women and all adolescents will get pushed to use protective measures against cervical cancer and have protected sexual behaviour.

Аpproximately 50–80% of sexually active women are exposed to at least one HPV variant during their lifetime. Based on the 2015 annual report of the National Institute of Public Health of Kosova, 68 new cases of cervical cancer were detected. The aim of the study was to investigate the attitude and practice regarding Human Papillomavirus (HPV) infections and the Human Papillomavirus vaccine in the population of the Republic of Kosova. Material and methods: A cross-sectional survey was conducted to assess the knowledge concerning HPV infections among the population aged 18 to 35+ years. The study was conducted during the period of time June 2021 –to August 2021. The sample included 500 participants. The questionnaire was anonymous, and participants were free to end their participation any time, without completing the questionnaire. Results: Regarding the claim "The HPV vaccine is safe", more than half of the respondents, respectively58.6% declare that they do not know, 33.4% of the respondents agree, 6.0% gave an incorrect answer / disagree, and 2.0% did not answer. The percentage difference between the unknown and correct answers is statistically significant for p<0.05. Conclusion: This study found out that the attitude towards the HPV vaccine among people of the Republic of Kosova is low to moderate. HPV vaccines should be included in the national immunization programs, since there is not still established national vaccination program for HPV vaccination.

Introduction: Non-obstetric vulvar hematomas are rare emergencies and there are no guidelines with defined recommendations for the treatment. They constitute up to 0.8% of all gynecological admissions and occur as a result of perineal trauma when compression of soft vulvar tissues against the osseous planes causes damage to the vulvar vascular complex.Case Report: We present a case of a non-obstetric vulvar hematoma in a 19-year-old woman resulting from the blunt trauma of the vulvar region. Conclusion:Our experience suggests that surgical intervention, in the setting of an expanding vulvar hematoma, reduces length of hospital stay and minimizes associated morbidity.