The role of oxidative stress in patients with recurrent pregnancy loss: a review

Zejnullahu, Vjosa A.; Kosumi, Ernad

doi:10.1186/s12978-021-01257-x

Cited by 38 publications

(40 citation statements)

References 93 publications

(120 reference statements)

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“…The total antioxidant status was significantly lower in the early onset severe PE group than in the uncomplicated pregnancies one [ 61 ]. A recent review states that there is evidence to support the hypothesis that increased OS and a deficient antioxidant defense is involved in the etiology of recurrent pregnancy loss [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

et al. 2022

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Ultra-processed food (UPF) consumption during gestation may lead to increased oxidative stress (OS) and could affect pregnancy outcomes. This study aims to evaluate the association of UPF consumption during pregnancy with circulating levels of OS markers. Diet was assessed (average of three assessments) in 119 pregnant women enrolled in the OBESO perinatal cohort (Mexico), obtaining quantitative data and the percentage of energy that UPFs (NOVA) contributed to the total diet. Sociodemographic, clinical (pregestational body-mass index and gestational weight gain) and lifestyle data were collected. Maternal circulating levels of OS markers (malondialdehyde (MDA), protein carbonylation (PC), and total antioxidant capacity (TAC)) were determined at the third trimester of pregnancy. Adjusted linear regression models were performed to analyze the association between UPFs and OS markers. UPFs represented 27.99% of the total energy intake. Women with a lower UPF consumption (<75 percentile°) presented a higher intake of fiber, ω-3, ω-6, and a lower ω-6/3 ratio. Linear regression models showed that UPFs were inversely associated with TAC and MDA. Fiber intake was associated with PC. UPF intake during pregnancy may result in an increase in oxidative stress. When providing nutrition care, limiting or avoiding UPFs may be an intervention strategy that could promote a better antioxidant capacity in the body.

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Section: Discussionmentioning

confidence: 99%

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

et al. 2022

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“…However, GNAQ activates the antioxidant properties of the Nrf2 protein and prevents cell damage (20). Placental oxidative stress has been linked to the development of RPL (21). The histone variant encoded by H2AFZ is an essential component of the nucleosome and affects the structure and function of eukaryotic chromatin (22).…”

Section: Discussionmentioning

confidence: 99%

Exploration of the Shared Gene and Molecular Mechanisms Between Endometriosis and Recurrent Pregnancy Loss

et al. 2022

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Endometriosis (EMs) is a common benign gynecological disease in women of childbearing age, which usually causes pelvic pain, secondary dysmenorrhea, and infertility. EMs has been linked to recurrent pregnancy loss (RPL) in epidemiological data. The relationship of both, however, remains unknown. The purpose of this study is to explore the underlying pathological mechanisms between EMs and RPL. We searched Gene Expression Omnibus (GEO) database to obtain omics data of EMs and RPL. Co-expression modules for EMs and RPL were investigated by using weighted gene co-expression network analysis (WGCNA). The intersections of gene modules with the strong correlation to EMs or RPL obtained by WGCNA analysis were considered as shared genes. MicroRNAs (miRNAs) and their corresponding target genes linked to EMs and RPL were found though the Human MicroRNA Disease Database (HMDD) and the miRTarbase database. Finally, we constructed miRNAs-mRNAs regulatory networks associated with the two disorders by using the intersection of previously obtained target genes and shared genes. We discovered as significant modules for EMs and RPL, respectively, by WGCNA. The energy metabolism might be the common pathogenic mechanism of EMs and RPL, according to the findings of a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We discovered several target genes that might be linked to these two disorders, as well as the potential mechanisms. RAB8B, GNAQ, H2AFZ, SUGT1, and LEO1 could be therapeutic candidates for RPL and EMs. The PI3K-Akt signaling pathway and platelet activation were potentially involved in the mechanisms of EM-induced RPL. Our findings for the first time revealed the underlying pathological mechanisms of EM-induced RPL and identified several useful biomarkers and potential therapeutic targets.

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“…Higher levels of such HM as antimony and arsenic have been reported in women with RPL (Alrashed et al, 2021). Reduction in antioxidants and increased lipid peroxidation and oxidative DNA damage have been reported in women with recurrent pregnancy loss (Zejnullahu, Zejnullahu, & Kosumi, 2021).…”

Section: Introductionmentioning

confidence: 98%

Impact of some heavy metal pollution on idiopathic recurrent spontaneous abortion

El-Sikaily

Helal

Nsonwu-Anyanwu

et al. 2023

Preprint

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Background Environmental pollution with heavy metal (HM) may be associated with human reproductive failure where pollutants are accumulated in marine organisms and sediment and subsequently transferred to man through food chain. Oxidative stress and disruption of homeostatic regulation of reproductive hormones has been implicated in HM induced reproductive toxicity. The HM, indices of oxidative stress, reproductive hormone and red cell indices in women with recurrent pregnancy loss (RPL) were assessed in this study. Methods Seventy-six women (20–35 years) categorized into 18 fertile women without RPL (control group), and Groups I, II and III comprising 24, 18 and 16 women with RPL (2, 3, and > 3 abortions respectively) were studied. Whole blood samples were collected for the estimation of cadmium (Cd), lead (Pb), metallothionein (rbcMT), malondialdehyde (MDA), reduced glutathione (GSH), progesterone, haemoglobin (Hb), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). Mussel samples were collected for Cd, Pb and metallothionein (MT) estimation. Results The cadmium content of mussels were above the maximum limit. Women with RPL (Groups I-III) had higher Cd, Pb, rbcMT and MDA and lower catalase, GSH, P4, Hb, MCV and MCH compared to Group I (p = < 0.001). Negative associations were observed between Cd and catalase (r=-0.320, p = 0.014), GSH (r=-0.359, p=-0.006) and MCV (r=-0.391, p=-0.002) respectively and between Pb and GSH (r=-0.501, p = < 0.001), Hb (r=-0.289, p = 0.028), MCV (r=-0.394, p = 0.002) and MCH (r=-0.277, p = 0.036) respectively in women with RPL. Positive correlations were observed between Cd and Pb (r = 0.533, p = < 0.001), rbcMT with Cd (r = 0.312, p = 0.017), Pb (r = 0.488, p = < 0.000) and MDA (r = 0.282, p = 0.032) respectively in women with RPL. Conclusion Elevated cadmium levels in mussels, metallothionein, MDA and reduced antioxidants, progesterone and red cell indices observed in women with RPL suggest that HM induced oxidative stress and hormonal imbalance may be implicated in recurrent pregnancy loss.

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The role of oxidative stress in patients with recurrent pregnancy loss: a review

Cited by 38 publications

References 93 publications

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

Exploration of the Shared Gene and Molecular Mechanisms Between Endometriosis and Recurrent Pregnancy Loss

Impact of some heavy metal pollution on idiopathic recurrent spontaneous abortion

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