Actinobacillus actinomycetemcomitans, an important pathogen in periodontitis, has also been detected in cardiovascular tissues. Sixty heart valves were collected during valve replacement surgery from 60 patients (one from each), 10 were from patients with infective endocarditis (IE group) and 50 were from patients with other valvular diseases (non-IE group). In addition, 46 samples of aneurysmal tissue were taken from 46 patients with a thoracic or abdominal aneurysm (Aneurysm group, one from each). Dental plaque samples were taken from 54 of the patients, 31 in the IE and non-IE groups and 23 in the aneurysm group. First, the distribution of A. actinomycetemcomitans in all specimens was analysed using a polymerase chain reaction method, which resulted in a positive reaction in 33 (31.1%) of the cardiovascular specimens and 25 (46.3%) of the dental plaque samples. Next, using serotype-specific sets of primers, the serotype distribution of A. actinomycetemcomitans in the cardiovascular specimens and dental plaque samples was found to be significantly different compared to dental plaque samples from Japanese subjects reported previously.
Subjects possessing red complex species may be at possible risk for infection with a high number of periodontal bacterial species during adolescent and younger adult years.
We present a case of Sotos syndrome. A 2-year-1-month-old Japanese boy diagnosed with Sotos syndrome was referred to our clinic for an oral examination. His growth from birth to the age of 4 years 11 months was pronounced above the 97th percentile. The primary teeth erupted extremely early, with the lower central incisors appearing at the age of 5 months, and all the primary teeth except the lower lateral incisors erupted by the age of 2 years 1 month. In addition, the lower permanent first molar erupted at the age of 4 years 6 months. However, mean dental age did not advance with chronological age. The tooth morphology appeared to be normal, however, the primary teeth were easily degraded by attrition, suggesting the poor calcification. A radiographic examination showed congenital missing of the lower primary and permanent lateral incisors, second premolars, and upper first premolars. In addition, the roots of the primary molars were extremely long and the ration of root length to crown length shown in panoramic radiographs was high. 97th percentile for age 2). It was recently reported that the syndrome is caused by a mutation in the gene for the nuclear receptor-binding SET domain-containing protein (NSD1) 5). There are few studies regarding oral manifestations associated with Sotos syndrome. Callanan et al. 6) reported a patient with Class 1 malocclusion with lower anterior crowding and severe dental caries in the primary molars. Further, congenital missing was found for all premolars, all third molars, the upper lateral incisors, and the lower left second molar in the permanent dentition. In another study, Inokuchi et al. 7) found enamel hypoplasia in all the primary canines and molars, and congenital missing of the upper first and second premolars, though no dental caries were observed. In the present report, the dental manifestations of a patient with Sotos syndrome are presented.
Four patients with hypophosphatasia, including twin brothers and younger and older sisters, were analyzed longitudinally. Ten periodontitisrelated bacterial species in dental plaque were detected using a Polymerase chain reaction (PCR) method with species-specific sets of primers. Further, clinical parameters related to periodontal conditions were recorded at each visit. One of the twins, who had experienced early exfoliation of the primary teeth, had a greater number of bacterial species than his brother, who had no alveolar bone loss. Both of the sisters experienced early exfoliation of their primary teeth, and the average numbers of tested bacterial species were higher in other subjects of the same age. Our results indicate that impaired cementum tissue caused by hypophosphatasia may produce favorable sites for colonization of periodontitis-related bacteria. based on the age of onset and clinical features; perinatal, infantile, childhood and adult types, and odontohypophosphatasia, in which only the teeth are affected 5). There have been a few reports regarding oral manifestations associated with this disease. The most consistent clinical signs are premature exfoliation of primary teeth and large pulp chambers 6). Although many reports describe primary teeth in patients with these symptoms, only a few have reported patients with permanent teeth 7,8). Premature exfoliation of primary teeth is thought to be caused by a disturbed formation of cementum, though some reports have noted that accumulation of bacteria accelerates exfoliation 9). In the present study, we investigated 4 subjects with hypophosphatasia, 2 of whom were twin brothers, and 2 of whom were different aged sisters. Dental findings focused on periodontal conditions were investigated, along with clinical diagnosis and detection of 10 periodontitis-related bacterial species using a molecular microbiological technique.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.