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Hybrid materials (HMs) based on a combination of bacterial cellulose (BC) and hydroxyapatite (HA) have demonstrated promising capabilities, especially for bone repair. The insertion of strontium into a BC/HA matrix has a role in the body related to bone remodeling. This study aimed to obtain HMs containing BC/HA doped with strontium ions (Sr 2?) by two routes of synthesis, differing in the way strontium was inserted. The HMs produced were characterized to elucidate the morphology and metal/ biopolymer interaction, and also strontium adsorption/ desorption profiles were evaluated. The biomaterials produced were able to interact with Sr 2? , showing a distinct adsorption/desorption profile for each material. BC/CaHA/Sr showed an ion exchange between Ca 2? present in hydroxyapatite by the Sr 2? in solution, characterized by mainly a physisorption mechanism. BC/SrAp demonstrated a chemical bond of Sr 2? on the BC surface by a chemisorption mechanism. The desorption study showed that the Sr release reached a plateau after 11 and 60 days and after 4 months, 91 and 6% of the adsorbed Sr 2? was released by BC/CaHA/Sr and BC/SrAp, respectively. These results suggest that the delivery of Sr 2? can be modulated during bone repair depending on the way Sr 2? is inserted into the hybrid matrix.

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