Advances in Bacterial Cellulose/Strontium Apatite Composites for Bone Applications

Maia, Marcella T.; Luz, Erika Patricia Chagas Gomes; Andrade, Fábia Karine; Rosa, Morsyleide de Freitas; Borges, M. de F.; Arcanjo, Maria Rosiene Antunes; Vieira, Rodrigo Silveira

doi:10.1080/15583724.2021.1896543

Cited by 13 publications

(3 citation statements)

References 125 publications

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“…This scaffold was designed to enhance cell proliferation and attachment while improving the mechanical properties of BC through the incorporation of PCL and gel [219]. Moreover, Maia et al developed a hybrid scaffold of BC/HA that promotes the internal migration, proliferation, and differentiation of boneforming cells and angiogenesis more effectively than BC alone, due to the biological activity of HA [220]. BC has been studied not only for soft tissue scaffolds but also for drug-eluting bone cements.…”

Section: Bc In Skin and Bone Tissue Engineering Applicationsmentioning

confidence: 99%

Fermentation Techniques and Biotechnological Applications of Modified Bacterial Cellulose: An Up-to-Date Overview

Sayah,

Gervasi,

Achour

et al. 2024

Fermentation

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Bacterial cellulose (BC) is a pure exocellular polysaccharide produced by micro-organisms. It has several properties in comparison with plant-derived cellulose that make it perfectly suitable for many applications, ranging from the food industry to the biomedical area. Different production methods and modification or functionalization procedures have been investigated in response to the many possible attractive applications of BC. This review overviews the different fermentation techniques and functionalization methods together with the main possible biotechnological applications of BC for food industry and biomedical purposes.

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Section: Bc In Skin and Bone Tissue Engineering Applicationsmentioning

confidence: 99%

Fermentation Techniques and Biotechnological Applications of Modified Bacterial Cellulose: An Up-to-Date Overview

Sayah,

Gervasi,

Achour

et al. 2024

Fermentation

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“…In addition, this hybrid system possesses outstanding properties, such as mechanical properties, conformability, elasticity, and cytocompatibility, owing to the synergistic behavior of both phases as compared to a single phase. In addition, the BNC/HAp multiphase system, including the incorporation of metal cations (e.g., strontium) to enhance functional ability [110]. BNC/HAp composite scaffolds are very promising in hard tissue regeneration, but it shows a few limitations due to low in vivo degradability.…”

Section: Bacterial Nanocellulose/filler-based Biomaterialsmentioning

confidence: 99%

Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review

Kumar

Han

2021

Materials

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Bacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due to its excellent biocompatibility (in vitro and in vivo), high water-holding capacity, flexibility, high mechanical properties, and a large number of hydroxyl groups that are most similar characteristics of native tissues, BNC has shown great potential in tissue engineering applications. This review focuses on and discusses the efficacy of BNC- or BNC-based biomaterials for hard tissue regeneration. In this review, we provide brief information on the key aspects of synthesis and properties of BNC, including solubility, biodegradability, thermal stability, antimicrobial ability, toxicity, and cellular response. Further, modification approaches are discussed briefly to improve the properties of BNC or BNC-based structures. In addition, various biomaterials by using BNC (as sacrificial template or matrix) or BNC in conjugation with polymers and/or fillers are reviewed and discussed for dental and bone tissue engineering applications. Moreover, the conclusion with perspective for future research directions of using BNC for hard tissue regeneration is briefly discussed.

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“…In the literature, there are limited studies on the biocompatibility of doped and un-doped strontium apatite (SrAp) [ 37 , 38 ]. In addition, studies on the in vivo biocompatibility of B-doped apatite nanoparticles are limited [ 28 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

Öztekin

Gürgenç

Dündar

et al. 2022

JFB

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In the present study, the structural, morphological, and in vivo biocompatibility of un-doped and boron (B)-doped strontium apatite (SrAp) nanoparticles were investigated. Biomaterials were fabricated using the hydrothermal process. The structural and morphological characterizations of the fabricated nanoparticles were performed by XRD, FT-IR, FE-SEM, and EDX. Their biocompatibility was investigated by placing them in defects in rat tibiae in vivo. The un-doped and B-doped SrAp nanoparticles were successfully fabricated. The produced nanoparticles were in the shape of nano-rods, and the dimensions of the nano-rods decreased as the B ratio increased. It was observed that the structural and morphological properties of strontium apatite nanoparticles were affected by the contribution of B. A stoichiometric Sr/P ratio of 1.67 was reached in the 5% B-doped sample (1.68). The average crystallite sizes were 34.94 nm, 39.70 nm, 44.93 nm, and 48.23 nm in un-doped, 1% B-doped, 5% B-doped, and 10% B-doped samples, respectively. The results of the in vivo experiment revealed that the new bone formation and osteoblast density were higher in the groups with SrAp nanoparticles doped with different concentrations of B than in the control group, in which the open defects were untreated. It was observed that this biocompatibility and the new bone formation were especially elevated in the B groups, which added high levels of strontium were added. The osteoblast density was higher in the group in which the strontium element was placed in the opened bone defect compared with the control group. However, although new bone formation was slightly higher in the strontium group than in the control group, the difference was not statistically significant. Furthermore, the strontium group had the highest amount of fibrotic tissue formation. The produced nanoparticles can be used in dental and orthopedic applications as biomaterials.

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Advances in Bacterial Cellulose/Strontium Apatite Composites for Bone Applications

Cited by 13 publications

References 125 publications

Fermentation Techniques and Biotechnological Applications of Modified Bacterial Cellulose: An Up-to-Date Overview

Fermentation Techniques and Biotechnological Applications of Modified Bacterial Cellulose: An Up-to-Date Overview

Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review

In Vivo Evaluation of the Effects of B-Doped Strontium Apatite Nanoparticles Produced by Hydrothermal Method on Bone Repair

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