No abstract

No abstract

Background: Proteases trigger inflammation and pain by cleaving protease-activated receptors (PARs) at defined sites. Results: Cathepsin S (Cat-S) cleaved PAR 2 at a unique site E 56 2T 57 , leading to G␣s-mediated cAMP accumulation and TRPV4-dependent inflammation and pain. Conclusion: Cat-S is a biased agonist of PAR 2 -and TRPV4-dependent inflammation and pain. Significance: PARs integrate responses to diverse proteases.

PAGE 27220:The N-terminal amino acid sequence of PAR2 in Fig. 1A is not correct because a repeat of an amino acid sequence (11-16, GAAILL) was accidentally inserted into positions 17-22. The correct sequence is shown in the revised Fig. 1A. This correction does not affect the results or conclusions of this work.

No abstract